The role of intraspecies variation in fish neurobehavioral and neuropharmacological phenotypes in aquatic models
Demin K. A., Lakstygal A. M., Alekseeva P. A., Sysoev M., de A. M. S., Alpyshov E. T., Serikuly N., Wang D., Wang M., Tang Z., Yan D., Strekalova T. V., Volgin A. D., Amstislavskaya T. G., Wang J., Song C., Kalueff A. V.
Aquatic Toxicology
Vol.210, P. 44-55
Опубликовано: 2019
Тип ресурса: Обзор
DOI:10.1016/j.aquatox.2019.02.015
Аннотация:
Intraspecies variation is common in both clinical and animal research of various brain disorders. Relatively well-studied in mammals, intraspecies variation in aquatic fish models and its role in their behavioral and pharmacological responses remain poorly understood. Like humans and mammals, fishes show high variance of behavioral and drug-evoked responses, modulated both genetically and environmentally. The zebrafish (Danio rerio) has emerged as a particularly useful model organism tool to access neurobehavioral and drug-evoked responses. Here, we discuss recent findings and the role of the intraspecies variance in neurobehavioral, pharmacological and toxicological studies utilizing zebrafish and other fish models. We also critically evaluate common sources of intraspecies variation and outline potential strategies to improve data reproducibility and translatability. © 2019 Elsevier B.V.
Ключевые слова:
Aquatic models; Individuality; Intraspecies variation; Neurobehavioral variation; Zebrafish
drug; brain; cyprinid; drug; intraspecific variation; modeling; phenotype; research; adaptation; age distribution; animal behavior; aquatic species; behavior; biological variation; central nervous system; diet; drug response; embryotoxicity; environmental factor; epigenetics; fish; genetic difference; genotype environment interaction; heredity; intestine flora; laboratory; mental function; neuropharmacology; neurotoxicity; nonhuman; personality; phenotype; priority journal; reproducibility; Review; sex difference; social behavior; social environment; species difference; strain difference; water pollution; zebra fish; animal; biological model; drug effect; genetics; human; nervous system function; phenotype; physiology; sexual characteristics; species difference; toxicity; water pollutant; Animalia; Danio rerio; Mammalia; Pisces; Animals; Behavior, Animal; Gene-Environment Interaction; Humans; Models, Biological; Nervous System Physiological Phenomena; Phenotype; Reproducibility of Resu
Язык текста: Английский
ISSN: 1879-1514
Demin K. A.
Lakstygal A. M.
Alekseeva P. A.
Sysoev M.
de A. M. S. Abreu M.S.
Alpyshov E. T.
Serikuly N.
Wang D.
Wang M.
Tang Z.
Yan D.
Strekalova T. V. Tat`yana Valeryevna 1969-
Volgin A. D.
Amstislavskaya T. G.
Wang J.
Song C.
Kalueff A. V.
Демин К. А.
Лакстyгал А. М.
Алексеева П. А.
Сyсоев М.
де А. М. С. Абреу М.С.
Алпyшов Е. Т.
Серикулy Н.
Wанг Д.
Wанг М.
Танг З.
Ян Д.
Стрекалова Т. В. Татьяна Валерьевна 1969-
Волгин А. Д.
Амстиславскайа Т. Г.
Wанг Й.
Сонг C.
Калуефф А. В.
The role of intraspecies variation in fish neurobehavioral and neuropharmacological phenotypes in aquatic models
Текст визуальный непосредственный
Aquatic Toxicology
Elsevier Science Publisher B.V.
Vol.210 P. 44-55
2019
Обзор
Aquatic models Individuality Intraspecies variation Neurobehavioral variation Zebrafish
drug brain cyprinid drug intraspecific variation modeling phenotype research adaptation age distribution animal behavior aquatic species behavior biological variation central nervous system diet drug response embryotoxicity environmental factor epigenetics fish genetic difference genotype environment interaction heredity intestine flora laboratory mental function neuropharmacology neurotoxicity nonhuman personality phenotype priority journal reproducibility Review sex difference social behavior social environment species difference strain difference water pollution zebra fish animal biological model drug effect genetics human nervous system function phenotype physiology sexual characteristics species difference toxicity water pollutant Animalia Danio rerio Mammalia Pisces Animals Behavior, Animal Gene-Environment Interaction Humans Models, Biological Nervous System Physiological Phenomena Phenotype Reproducibility of Resu
Intraspecies variation is common in both clinical and animal research of various brain disorders. Relatively well-studied in mammals, intraspecies variation in aquatic fish models and its role in their behavioral and pharmacological responses remain poorly understood. Like humans and mammals, fishes show high variance of behavioral and drug-evoked responses, modulated both genetically and environmentally. The zebrafish (Danio rerio) has emerged as a particularly useful model organism tool to access neurobehavioral and drug-evoked responses. Here, we discuss recent findings and the role of the intraspecies variance in neurobehavioral, pharmacological and toxicological studies utilizing zebrafish and other fish models. We also critically evaluate common sources of intraspecies variation and outline potential strategies to improve data reproducibility and translatability. © 2019 Elsevier B.V.