Age-related immune response to measles virus in staff of a large city hospital
Костинов М. П., Филатов Н. Н., Журавлев П. И., Гладкова Л. С., Полишчук В. Б., Шмит’ко А. Д., Пахомов Д. В., Хромова Е. А., Костинова А. М., Васил’ьева Г. В., Тихонова И. А., Рyжов А. А., Благовидов Д. А., Костинов А. М.
Пульмонология
Т. 28, Вып. 6, С. 701-707
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.18093/0869-0189-2018-28-6-701-707
Аннотация:
The aims of the study were to examine age-related features of immune response to measles virus in staff of a large city hospital and to define groups at risk for measles outbreaks. Methods. The study involved 1,855 staff members of a large city hospital aged ≥ 19 years old who had documented vaccination against measles or a history of measles. The participants were divided into age groups with 5-year intervals starting from 19 years of age; there were 11 groups in total. The immune response to measles virus was measured in sera by ELISA using Vector-Best IgG-Kor test system (Russia). Results. Young employers of 19 to 23 years of age were most susceptible to measles; protective antibody level was not detected in 38.5[%] of them. They were followed by young-to-middle-aged workers (24 to 48 years old) who were negative for anti-measles antibodies or had non-protective level of antibodies in 16.7[%] to 27.5[%]. The anti-measles antibody level was low (42.3 [%] to 60.0 [%]) in employers of 19 to 43 y
Ключевые слова:
Antibodies; Immunity; Measles; Medical staff
measles antibody; measles vaccine; adult; antibody detection; Article; epidemic; human; immune response; infection prevention; infection risk; infection sensitivity; major clinical study; measles; measles vaccination; Measles virus; medical staff; nonhuman; occupational disease
Язык текста: Русский
ISSN: 0869-0189
Костинов М. П. Михаил Петрович 1956-
Филатов Н. Н. Николай Николаевич 1954-
Журавлев П. И.
Гладкова Л. С.
Полишчук В. Б.
Шмит’ко А. Д.
Пахомов Д. В.
Хромова Е. А.
Костинова А. М.
Васил’ьева Г. В.
Тихонова И. А.
Рyжов А. А.
Благовидов Д. А.
Костинов А. М.
Kostinov M. P. Mikhail Petrovich 1956-
Filatov N. N. Nikolay Nikolaevich 1954-
Zhuravlev P. I.
Gladkova L. S.
Polishchuk V. B.
Shmit’ko A. D.
Pakhomov D. V.
Khromova E. A.
Kostinova A. M.
Vasil’yeva G. V.
Tikhonova I. A.
Ryzhov A. A.
Blagovidov D. A.
Kostinov A. M.
Age-related immune response to measles virus in staff of a large city hospital
Текст визуальный непосредственный
Пульмонология
Научно-практический журнал "Пульмонология"
Т. 28, Вып. 6 С. 701-707
2018
Статья
Antibodies Immunity Measles Medical staff
measles antibody measles vaccine adult antibody detection Article epidemic human immune response infection prevention infection risk infection sensitivity major clinical study measles measles vaccination Measles virus medical staff nonhuman occupational disease
The aims of the study were to examine age-related features of immune response to measles virus in staff of a large city hospital and to define groups at risk for measles outbreaks. Methods. The study involved 1,855 staff members of a large city hospital aged ≥ 19 years old who had documented vaccination against measles or a history of measles. The participants were divided into age groups with 5-year intervals starting from 19 years of age; there were 11 groups in total. The immune response to measles virus was measured in sera by ELISA using Vector-Best IgG-Kor test system (Russia). Results. Young employers of 19 to 23 years of age were most susceptible to measles; protective antibody level was not detected in 38.5[%] of them. They were followed by young-to-middle-aged workers (24 to 48 years old) who were negative for anti-measles antibodies or had non-protective level of antibodies in 16.7[%] to 27.5[%]. The anti-measles antibody level was low (42.3 [%] to 60.0 [%]) in employers of 19 to 43 y