Bulletin of Experimental Biology and Medicine
Vol.166, Issue4, P. 456-460
Аннотация:
We performed an in vivo comparative study of activity of three substances of the nitrosourea group produced in Russia. All substances demonstrated high antitumor activity against various solid and leukemic tumors. Aranosa significantly enhanced life duration in mice with leukemia (by 65-194[%]) and inhibited the growth of solid tumors (by 49-99.6[%]). Lisomustine and ormustine showed higher activity than aranose. Single administration of lisomustine increased life span of mice (by 22-114[%]) and resulted in cure of all animals in four models: lymphoblastic leukemia L-1210, lymphocytic leukemia P-388, Lewis lung carcinoma, and cervical cancer RShM-5. After ormustine treatment, full recovery was observed only in groups with lymphocytic leukemia P-388 and cervical cancer RShM-5. These findings attest to higher activity of lisomustine in the studied models. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
Ключевые слова:
antitumor activity; nitrosourea-based substances; tumor
antineoplastic agent; aranose; lisomustine; nitrosourea; ormustine; unclassified drug; antineoplastic agent; nitrosourea derivative; animal cell; antineoplastic activity; Article; cancer chemotherapy; cancer graft; comparative study; controlled study; in vivo study; Lewis carcinoma; lifespan; lymphatic leukemia; melanoma B16; mouse; nonhuman; Russian Federation; single drug dose; solid malignant neoplasm; uterine cervix cancer; animal; experimental neoplasm; female; leukemia L 1210; leukemia P 388; male; treatment outcome; uterine cervix tumor; Animals; Antineoplastic Agents; Female; Leukemia L1210; Leukemia P388; Male; Mice; Neoplasms, Experimental; Nitrosourea Compounds; Russia; Treatment Outcome; Uterine Cervical Neoplasms
Bunyatyan N. D. Natal`ya Dmitrievna 1955-
Oborotova N. A. Nataliya Aleksandrovna 1949-
Nikolaeva L. L. Lyudmila Leonidovna 1991-
Saprykina N. S.
Borisova L. M.
Kiseleva M. P.
Prokofyev A. B. Aleksej Borisovich 1964-
Бунятян Н. Д. Наталья Дмитриевна 1955-
Оборотова Н. А. Наталия Александровна 1949-
Николаева Л. Л. Людмила Леонидовна 1991-
Сапрyкина Н. С.
Борисова Л. М.
Киселева М. П.
Прокофьев А. Б. Алексей Борисович 1964-
Comparative Analysis of Bioactivity of the Russian-Made Antitumor Substances of the Nitrosourea Group
Текст визуальный непосредственный
Bulletin of Experimental Biology and Medicine
Springer New York Consultants Bureau
Vol.166, Issue4 P. 456-460
2019
Статья
antitumor activity nitrosourea-based substances tumor
antineoplastic agent aranose lisomustine nitrosourea ormustine unclassified drug antineoplastic agent nitrosourea derivative animal cell antineoplastic activity Article cancer chemotherapy cancer graft comparative study controlled study in vivo study Lewis carcinoma lifespan lymphatic leukemia melanoma B16 mouse nonhuman Russian Federation single drug dose solid malignant neoplasm uterine cervix cancer animal experimental neoplasm female leukemia L 1210 leukemia P 388 male treatment outcome uterine cervix tumor Animals Antineoplastic Agents Female Leukemia L1210 Leukemia P388 Male Mice Neoplasms, Experimental Nitrosourea Compounds Russia Treatment Outcome Uterine Cervical Neoplasms
We performed an in vivo comparative study of activity of three substances of the nitrosourea group produced in Russia. All substances demonstrated high antitumor activity against various solid and leukemic tumors. Aranosa significantly enhanced life duration in mice with leukemia (by 65-194[%]) and inhibited the growth of solid tumors (by 49-99.6[%]). Lisomustine and ormustine showed higher activity than aranose. Single administration of lisomustine increased life span of mice (by 22-114[%]) and resulted in cure of all animals in four models: lymphoblastic leukemia L-1210, lymphocytic leukemia P-388, Lewis lung carcinoma, and cervical cancer RShM-5. After ormustine treatment, full recovery was observed only in groups with lymphocytic leukemia P-388 and cervical cancer RShM-5. These findings attest to higher activity of lisomustine in the studied models. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.