The role of 5-ALA in low-grade gliomas and the influence of antiepileptic drugs on intraoperative fluorescence
Goryaynov S. A., Widhalm G., Gol`dberg M. F., Chelushkin D., Spallone A., Cherny'shov K. A., Ryzhova M., Pavlova G. V., Revischin A., Shishkina L., Jukov V., Savelieva T., Victor L., Potapov A.
Frontiers in Oncology
Vol.9, IssueMAY, Num.423
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.3389/fonc.2019.00423
Аннотация:
Objectives: Intraoperative tumor visualization with 5-aminolevulinic acid (5-ALA) induced protoporphyrin IX (PpIX) fluorescence is widely applied for improved resection of high-grade gliomas. However, visible fluorescence is present only in a minority of low-grade gliomas (LGGs) according to current literature. Nowadays, antiepileptic drugs (AEDs) are frequently administered to LGG patients prior to surgery. A recent in-vitro study demonstrated that AEDs result in significant reduction of PpIX synthesis in glioma cells. The aim of this study was thus to investigate the role of 5-ALA fluorescence in LGG surgery and the influence of AEDs on visible fluorescence. Patients and Methods: Patients with resection of a newly diagnosed suspected LGG after 5-ALA (25 mg/kg) administration were initially included. During surgery, the presence of visible fluorescence (none, mild, moderate, or bright) within the tumor and intratumoral fluorescence homogeneity (diffuse or focal) were analyzed. Tissue
Ключевые слова:
5-aminolevulinic acid; antiepileptic drugs; fluorescence; low-grade glioma; protoporphyrin IX
aminolevulinic acid; anticonvulsive agent; carbamazepine; levetiracetam; oxcarbazepine; protoporphyrin; valproic acid; adult; aged; Article; astrocytoma; cell density; cell proliferation assay; clinical article; cohort analysis; controlled study; female; fluorescence; glioma; histopathology; human; human tissue; in vitro study; intraoperative fluorescence; male; microscopy; middle aged; motor evoked potential; neurologic disease; neuromonitoring; neuronavigation; nuclear magnetic resonance imaging; oligodendroglioma; peroperative care; phonetics; phototoxicity; postoperative care; seizure; spectroscopy; ultraviolet radiation; young adult
Язык текста: Английский
ISSN: 2234-943X
Goryaynov S. A.
Widhalm G.
Gol`dberg M. F. Mariya Feliksovna 1994-
Chelushkin D.
Spallone A.
Cherny'shov K. A. Konstantin Alekseevich 1994-
Ryzhova M.
Pavlova G. V. Galina Valerievna 1967-
Revischin A.
Shishkina L.
Jukov V.
Savelieva T.
Victor L.
Potapov A.
Горyайнов С. А.
Wидхалм Г.
Гольдберг М. Ф. Мария Феликсовна 1994-
Челушкин Д.
Спаллоне А.
Чернышов К. А. Константин Алексеевич 1994-
Рyжова М.
Павлова Г. В. Галина Валериевна 1967-
Ревисчин А.
Шишкина Л.
Йуков В.
Савелиева Т.
Виcтор Л.
Потапов А.
The role of 5-ALA in low-grade gliomas and the influence of antiepileptic drugs on intraoperative fluorescence
Текст визуальный непосредственный
Frontiers in Oncology
Vol.9, IssueMAY Num.423
2019
Статья
5-aminolevulinic acid antiepileptic drugs fluorescence low-grade glioma protoporphyrin IX
aminolevulinic acid anticonvulsive agent carbamazepine levetiracetam oxcarbazepine protoporphyrin valproic acid adult aged Article astrocytoma cell density cell proliferation assay clinical article cohort analysis controlled study female fluorescence glioma histopathology human human tissue in vitro study intraoperative fluorescence male microscopy middle aged motor evoked potential neurologic disease neuromonitoring neuronavigation nuclear magnetic resonance imaging oligodendroglioma peroperative care phonetics phototoxicity postoperative care seizure spectroscopy ultraviolet radiation young adult
Objectives: Intraoperative tumor visualization with 5-aminolevulinic acid (5-ALA) induced protoporphyrin IX (PpIX) fluorescence is widely applied for improved resection of high-grade gliomas. However, visible fluorescence is present only in a minority of low-grade gliomas (LGGs) according to current literature. Nowadays, antiepileptic drugs (AEDs) are frequently administered to LGG patients prior to surgery. A recent in-vitro study demonstrated that AEDs result in significant reduction of PpIX synthesis in glioma cells. The aim of this study was thus to investigate the role of 5-ALA fluorescence in LGG surgery and the influence of AEDs on visible fluorescence. Patients and Methods: Patients with resection of a newly diagnosed suspected LGG after 5-ALA (25 mg/kg) administration were initially included. During surgery, the presence of visible fluorescence (none, mild, moderate, or bright) within the tumor and intratumoral fluorescence homogeneity (diffuse or focal) were analyzed. Tissue