Vascular cognitive impairment: Pathophysiological mechanisms, insights into structural basis, and perspectives in specific treatments
Parfenov V. A., Ostroumova O. D., Ostroumova T. M., Kochetkov A. I., Fateeva V. V., Khacheva K. K., Khakimova G. R., Epstein O. I.
Neuropsychiatric Disease and Treatment
Vol.15, P. 1381-1402
Опубликовано: 2019
Тип ресурса: Обзор
Аннотация:
Vascular cognitive impairment (VCI) and vascular dementia are the most common forms of cognitive disorder associated with cerebrovascular disease and related to increased morbidity and mortality among the older population. Growing evidence suggests the contribution of blood-pressure variability, cardiac arrhythmia, hyperactiva-tion of the renin–angiotensin–aldosterone system, endothelial dysfunction, vascular remodeling and stiffness, different angiopathies, neural tissue homeostasis, and systemic metabolic disorders to the pathophysiology of VCI. In this review, we focus on factors contributing to cerebrovascular disease, neurovascular unit alterations, and novel approaches to cognitive improvement in patients with cognitive decline. One of the important factors associated with the neuronal causes of VCI is the S100B protein, which can affect the expression of cytokines in the brain, support homeostasis, and regulate processes of differentiation, repair, and apoptosis of the nervous t
Ключевые слова:
Cerebrovascular disease; Endothelial dysfunction; Neurovascular unit; S100 protein; Vascular cognitive impairment
antibody; C reactive protein; D dimer; endothelial leukocyte adhesion molecule 1; endothelial nitric oxide synthase; homocysteine; intercellular adhesion molecule 1; interleukin 6; interleukin 8; monocyte chemotactic protein 1; PADGEM protein; protein S 100; protein S100B; prothrombin; reactive oxygen metabolite; reduced nicotinamide adenine dinucleotide phosphate oxidase; released active antibody; transforming growth factor beta; unclassified drug; uric acid; vascular cell adhesion molecule 1; vasculotropin; von Willebrand factor; aging; Alzheimer disease; amyotrophic lateral sclerosis; antidepressant activity; antioxidant activity; arterial stiffness; astrocyte; blood brain barrier; brain perfusion; capillary density; cerebrovascular accident; cerebrovascular disease; cognitive defect; dementia; diabetes mellitus; drug efficacy; drug safety; endothelial dysfunction; essential hypertension; gene overexpression; human; hypertensive vasculopathy; hyperuricemia; microglia; multiple scler
Язык текста: Английский
ISSN: 1178-2021
Parfenov V. A. Vladimir Anatolyevich 1957-
Ostroumova O. D. Ol`ga Dmitrievna 1968-
Ostroumova T. M. Tat`yana Maksimovna 1991-
Kochetkov A. I.
Fateeva V. V. Viktoriya Vyacheslavovna 1988-
Khacheva K. K.
Khakimova G. R.
Epstein O. I.
Парфенов В. А. Владимир Анатольевич 1957-
Остроумова О. Д. Ольга Дмитриевна 1968-
Остроумова Т. М. Татьяна Максимовна 1991-
Кочетков А. И.
Фатеева В. В. Виктория Вячеславовна 1988-
Хачева К. К.
Хакимова Г. Р.
Епстеин О. И.
Vascular cognitive impairment: Pathophysiological mechanisms, insights into structural basis, and perspectives in specific treatments
Текст визуальный непосредственный
Neuropsychiatric Disease and Treatment
Dove Medical Press Ltd.
Vol.15 P. 1381-1402
2019
Обзор
Cerebrovascular disease Endothelial dysfunction Neurovascular unit S100 protein Vascular cognitive impairment
antibody C reactive protein D dimer endothelial leukocyte adhesion molecule 1 endothelial nitric oxide synthase homocysteine intercellular adhesion molecule 1 interleukin 6 interleukin 8 monocyte chemotactic protein 1 PADGEM protein protein S 100 protein S100B prothrombin reactive oxygen metabolite reduced nicotinamide adenine dinucleotide phosphate oxidase released active antibody transforming growth factor beta unclassified drug uric acid vascular cell adhesion molecule 1 vasculotropin von Willebrand factor aging Alzheimer disease amyotrophic lateral sclerosis antidepressant activity antioxidant activity arterial stiffness astrocyte blood brain barrier brain perfusion capillary density cerebrovascular accident cerebrovascular disease cognitive defect dementia diabetes mellitus drug efficacy drug safety endothelial dysfunction essential hypertension gene overexpression human hypertensive vasculopathy hyperuricemia microglia multiple scler
Vascular cognitive impairment (VCI) and vascular dementia are the most common forms of cognitive disorder associated with cerebrovascular disease and related to increased morbidity and mortality among the older population. Growing evidence suggests the contribution of blood-pressure variability, cardiac arrhythmia, hyperactiva-tion of the renin–angiotensin–aldosterone system, endothelial dysfunction, vascular remodeling and stiffness, different angiopathies, neural tissue homeostasis, and systemic metabolic disorders to the pathophysiology of VCI. In this review, we focus on factors contributing to cerebrovascular disease, neurovascular unit alterations, and novel approaches to cognitive improvement in patients with cognitive decline. One of the important factors associated with the neuronal causes of VCI is the S100B protein, which can affect the expression of cytokines in the brain, support homeostasis, and regulate processes of differentiation, repair, and apoptosis of the nervous t