Аннотация:
Objective: To determine the incidence and analyze the clinical and diagnostic characteristics of the metabolic bone disease of prematurity (MBDP) presenting with non-traumatic fractures. Materials and methods. The study was conducted in 2013-2017 and comprised all premature infants with MBDP-associated bone fractures, who had no surgical diseases. Results: Fractures were diagnosed in 7 children; femoral and rib fractures were more common than humerus fractures. All children received total parenteral nutrition lasting from 9 to 43 (median 19) days; in 5 of them, enteral nutrition did not meet their nutritional needs. In the 1st month of life, all infants had severe hypophosphatemia; in 5 patients the level of alkaline phosphatase increased. Conclusion: MBDP-associated bone fractures were observed in 2.1[%] of children with birth weight less than 1500g (6.25[%] with ELBW; 0.4[%] with VLBW). All children had multiple risk factors for MBDP. In 3 infants, bone fractures were diagnosed belatedly,
Ключевые слова:
Bone fracture; Metabolic bone disease; Osteopenia; Premature infants
alkaline phosphatase; Article; child; clinical article; enteric feeding; femur fracture; fracture; human; humerus fracture; hypophosphatemia; incidence; metabolic bone disease; parenteral nutrition; prematurity; rib fracture
Кухарцева М. В. Марина Вячеславовна 1990-
Нароган М. В. Марина Викторовна 1975-
Козлова А. В.
Рюмина И. И. Ирина Ивановна 1955-
Орловскайа И. В.
Парнас А. Y. А.Ю.
Гурьева О. Е. Ольга Евгеньевна 1996-
Зубков В. В. Виктор Васильевич 1964-
Дегтярев Д. Н. Дмитрий Николаевич 1960-
Kukhartseva M. V. Marina Vyacheslavovna 1990-
Narogan M. V. Marina Viktorovna 1975-
Kozlova A. V.
Ryumina I. I. Irina Ivanovna 1955-
Orlovskaya I. V.
Parnas A. Y. A.Yu.
Guryeva O. E. Ol`ga Evgenyevna 1996-
Zubkov V. V. Viktor Vasilyevich 1964-
Degtyarev D. N. Dmitrij Nikolaevich 1960-
Clinical and diagnostic aspects of non-traumatic fractures in metabolic bone disease of prematurity
Текст визуальный непосредственный
Акушерство и гинекология
Бионика Медиа
Т. 2019, Вып. 3 С. 106-113
2019
Статья
Bone fracture Metabolic bone disease Osteopenia Premature infants
alkaline phosphatase Article child clinical article enteric feeding femur fracture fracture human humerus fracture hypophosphatemia incidence metabolic bone disease parenteral nutrition prematurity rib fracture
Objective: To determine the incidence and analyze the clinical and diagnostic characteristics of the metabolic bone disease of prematurity (MBDP) presenting with non-traumatic fractures. Materials and methods. The study was conducted in 2013-2017 and comprised all premature infants with MBDP-associated bone fractures, who had no surgical diseases. Results: Fractures were diagnosed in 7 children; femoral and rib fractures were more common than humerus fractures. All children received total parenteral nutrition lasting from 9 to 43 (median 19) days; in 5 of them, enteral nutrition did not meet their nutritional needs. In the 1st month of life, all infants had severe hypophosphatemia; in 5 patients the level of alkaline phosphatase increased. Conclusion: MBDP-associated bone fractures were observed in 2.1[%] of children with birth weight less than 1500g (6.25[%] with ELBW; 0.4[%] with VLBW). All children had multiple risk factors for MBDP. In 3 infants, bone fractures were diagnosed belatedly,