Assessment of hemostatic disturbances in women with established rheumatoid arthritis
Vranic A., Pruner I., Veselinovic M., Soutari N., Petkovic A., Yakovlevich V., Antovic A.
Clinical Rheumatology
Vol.38, Issue11, P. 3005-3014
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1007/s10067-019-04629-8
Аннотация:
Objectives: This study was aimed to assess hemostatic disturbances in female patients with established rheumatoid arthritis (RA) in relation to menopausal status and disease activity. Method: Ninety women were included in the study, 42 patients and 48 age-matched healthy controls. There were no differences between the investigated groups regarding the presence of traditional cardiovascular risk factors. Two global hemostatic assays were employed, namely endogenous thrombin potential (ETP) and overall hemostasis potential (OHP). The parameters of the ETP assay (ETP, C-max, t-lag, t-max) and OHP assay (overall coagulation potential (OCP) and overall fibrinolytic potential (OFP)) were assessed. Moreover, the parameters of the fibrin clot (lag time, Max Abs, and slope) were measured by clot turbidity and scanning electron microscopy (SEM). Both patients and controls were divided into four subgroups according to menopause status. Results: The premenopausal controls differed significantly fr
Ключевые слова:
Fibrin structure; Hemostasis; Menopause; Rheumatoid arthritis
C reactive protein; cholesterol; fibrinogen; high density lipoprotein; low density lipoprotein; methotrexate; prednisolone; thrombin; triacylglycerol; adult; area under the curve; Article; blood clotting; blood clotting disorder; cardiovascular risk; cholesterol blood level; clinical article; comparative study; controlled study; disease activity; disease duration; erythrocyte sedimentation rate; female; fibrin clot; fibrin polymerization; fibrinogen blood level; fibrinolysis; human; lipoprotein blood level; menopause; middle aged; premenopause; priority journal; protein blood level; rheumatoid arthritis; rheumatoid nodule; scanning electron microscopy; triacylglycerol blood level; case control study; hemostasis; pathophysiology; rheumatoid arthritis; Arthritis, Rheumatoid; Case-Control Studies; Female; Hemostasis; Humans; Menopause; Middle Aged
Язык текста: Английский
ISSN: 1434-9949
Vranic A.
Pruner I.
Veselinovic M.
Soutari N.
Petkovic A.
Yakovlevich V. Vladimir 1971-
Antovic A.
Враниc А.
Прунер И.
Веселиновиc М.
Соутари Н.
Петковиc А.
Яковлевич В. Владимир 1971-
Антовиc А.
Assessment of hemostatic disturbances in women with established rheumatoid arthritis
Текст визуальный непосредственный
Clinical Rheumatology
Springer-Verlag London Ltd
Vol.38, Issue11 P. 3005-3014
2019
Статья
Fibrin structure Hemostasis Menopause Rheumatoid arthritis
C reactive protein cholesterol fibrinogen high density lipoprotein low density lipoprotein methotrexate prednisolone thrombin triacylglycerol adult area under the curve Article blood clotting blood clotting disorder cardiovascular risk cholesterol blood level clinical article comparative study controlled study disease activity disease duration erythrocyte sedimentation rate female fibrin clot fibrin polymerization fibrinogen blood level fibrinolysis human lipoprotein blood level menopause middle aged premenopause priority journal protein blood level rheumatoid arthritis rheumatoid nodule scanning electron microscopy triacylglycerol blood level case control study hemostasis pathophysiology rheumatoid arthritis Arthritis, Rheumatoid Case-Control Studies Female Hemostasis Humans Menopause Middle Aged
Objectives: This study was aimed to assess hemostatic disturbances in female patients with established rheumatoid arthritis (RA) in relation to menopausal status and disease activity. Method: Ninety women were included in the study, 42 patients and 48 age-matched healthy controls. There were no differences between the investigated groups regarding the presence of traditional cardiovascular risk factors. Two global hemostatic assays were employed, namely endogenous thrombin potential (ETP) and overall hemostasis potential (OHP). The parameters of the ETP assay (ETP, C-max, t-lag, t-max) and OHP assay (overall coagulation potential (OCP) and overall fibrinolytic potential (OFP)) were assessed. Moreover, the parameters of the fibrin clot (lag time, Max Abs, and slope) were measured by clot turbidity and scanning electron microscopy (SEM). Both patients and controls were divided into four subgroups according to menopause status. Results: The premenopausal controls differed significantly fr