Extension of maximal lifespan and high bone marrow chimerism after nonmyeloablative syngeneic transplantation of bone marrow from young to old mice
Kovina M. V., Karnaukhov A. V., Krasheninnikov M. E., Kovin A. L., Gazheev S. T., Sergievich L. A., Karnaukhova E. V., Bogdanenko E. V., Balyasin M. V., Khodarovich Y. M., Dyuzheva T. G., Lyundup A. V.
Frontiers in genetics
Vol.10, IssueAPR, Num.310
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.3389/fgene.2019.00310
Аннотация:
The goal of this work was to determine the effect of nonablative syngeneic transplantation of young bone marrow (BM) to laboratory animals (mice) of advanced age upon maximum duration of their lifespan. To do this, transplantation of 100 million nucleated cells from BM of young syngeneic donors to an old nonablated animal was performed at the time when half of the population had already died. As a result, the maximum lifespan (MLS) increased by 28 ± 5[%], and the survival time from the beginning of the experiment increased 2.8 ± 0.3-fold. The chimerism of the BM 6 months after the transplantation was 28[%]. Copyright © 2019 Kovina, Karnaukhov, Krasheninnikov, Kovin, Gazheev, Sergievich, Karnaukhova, Bogdanenko, Balyasin, Khodarovich, Dyuzheva and Lyundup. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s)
Ключевые слова:
Bone marrow transplantation; Cryobank; Life extension; Longevity; Mesenchymal stem cells
adult; animal cell; animal experiment; animal tissue; article; bone marrow transplantation; chimera; controlled study; female; isotransplantation; life extension; longevity; male; mesenchymal stem cell; mouse; nonhuman; survival time
Язык текста: Английский
ISSN: 1664-8021
Kovina M. V. Marina Valentinovna 1965-
Karnaukhov A. V.
Krasheninnikov M. E. Mikhail Evgenyevich 1959-
Kovin A. L.
Gazheev S. T.
Sergievich L. A.
Karnaukhova E. V.
Bogdanenko E. V.
Balyasin M. V. Maksim Vitalyevich 1996-
Khodarovich Y. M.
Dyuzheva T. G. Tat`yana Gennadyevna 1952-
Lyundup A. V. Aleksej Valeryevich 1983-
Ковина М. В. Марина Валентиновна 1965-
Карнаухов А. В.
Крашенинников М. Е. Михаил Евгеньевич 1959-
Ковин А. Л.
Гажеев С. Т.
Сергиевич Л. А.
Карнаухова Е. В.
Богданенко Е. В.
Балясин М. В. Максим Витальевич 1996-
Ходарович Y. М.
Дюжева Т. Г. Татьяна Геннадьевна 1952-
Люндуп А. В. Алексей Валерьевич 1983-
Extension of maximal lifespan and high bone marrow chimerism after nonmyeloablative syngeneic transplantation of bone marrow from young to old mice
Текст визуальный непосредственный
Frontiers in genetics
Vol.10, IssueAPR Num.310
2019
Статья
Bone marrow transplantation Cryobank Life extension Longevity Mesenchymal stem cells
adult animal cell animal experiment animal tissue article bone marrow transplantation chimera controlled study female isotransplantation life extension longevity male mesenchymal stem cell mouse nonhuman survival time
The goal of this work was to determine the effect of nonablative syngeneic transplantation of young bone marrow (BM) to laboratory animals (mice) of advanced age upon maximum duration of their lifespan. To do this, transplantation of 100 million nucleated cells from BM of young syngeneic donors to an old nonablated animal was performed at the time when half of the population had already died. As a result, the maximum lifespan (MLS) increased by 28 ± 5[%], and the survival time from the beginning of the experiment increased 2.8 ± 0.3-fold. The chimerism of the BM 6 months after the transplantation was 28[%]. Copyright © 2019 Kovina, Karnaukhov, Krasheninnikov, Kovin, Gazheev, Sergievich, Karnaukhova, Bogdanenko, Balyasin, Khodarovich, Dyuzheva and Lyundup. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s)