Panax ginseng components and the pathogenesis of Alzheimer's disease (Review)
Razgonova M. P., Veselov V. V., Zakharenko A. M., Golokhvast K. S., Nosy'rev A. E., Kravotto D., Tsatsakis A., Spandidos D. A.
Molecular Medicine Reports
Vol.19, Issue4, P. 2975-2998
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.3892/mmr.2019.9972
Аннотация:
Ginseng is one of the main representatives of traditional Chinese medicine and presents a wide range of pharmacological actions. Ginsenosides are the main class of active compounds found in ginseng. They demonstrate unique biological activity and medicinal value, namely anti-tumour, anti-inflammatory and antioxidant properties, as well as anti-apoptotic properties. Increasing levels of stress in life are responsible for the increased incidence of nervous system diseases. Neurological diseases create a huge burden on the lives and health of individuals. In recent years, studies have indicated that ginsenosides play a pronounced positive role in the prevention and treatment of neurological diseases. Nevertheless, research is still at an early stage of development, and the complex mechanisms of action involved remain largely unknown. This review aimed to shed light into what is currently known about the mechanisms of action of ginsenosides in relation to Alzheimer's disease. Scientific ma
Ключевые слова:
Alzheimer's disease; Ginseng; Ginsenosides; Nervous system diseases; β-amyloid level
acetylcholine; amyloid beta protein; brain derived neurotrophic factor; calcium ion; ginsenoside; ginsenoside Rb 1; ginsenoside Rb 2; ginsenoside Rb 3; ginsenoside Re; ginsenoside Rg 2; ginsenoside Rg 3; ginsenoside Rg 4; ginsenoside Rh 1; ginsenoside Rh 2; ginsenoside Rh 3; notoginsenoside R1; notoginsenoside st4; panaxadiol; protopanaxadiol; unclassified drug; acetylcholine; amyloid beta protein; ginsenoside; plant extract; Alzheimer disease; Article; chemical composition; cognition; drug mechanism; ginseng; human; nerve cell; nervous system inflammation; neurofibrillary tangle; nonhuman; pathogenesis; Pi3K/Akt signaling; Alzheimer disease; animal; chemistry; metabolism; Panax; Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Ginsenosides; Humans; Panax; Plant Extracts
Язык текста: Английский
ISSN: 1791-3004
Razgonova M. P.
Veselov V. V. Valerij Vyacheslavovich 1992-
Zakharenko A. M.
Golokhvast K. S.
Nosy'rev A. E. Aleksandr Evgenyevich 1958-
Kravotto D. Dzhankarlo 1961-
Tsatsakis A. Aristidis 1957-
Spandidos D. A.
Разгонова М. П.
Веселов В. В. Валерий Вячеславович 1992-
Захаренко А. М.
Голохваст К. С.
Носырев А. Е. Александр Евгеньевич 1958-
Кравотто Д. Джанкарло 1961-
Цацакис А. Аристидис 1957-
Спандидос Д. А.
Panax ginseng components and the pathogenesis of Alzheimer's disease (Review)
Текст визуальный непосредственный
Molecular Medicine Reports
Spandidos Publications Ltd.
Vol.19, Issue4 P. 2975-2998
2019
Статья
Alzheimer's disease Ginseng Ginsenosides Nervous system diseases β-amyloid level
acetylcholine amyloid beta protein brain derived neurotrophic factor calcium ion ginsenoside ginsenoside Rb 1 ginsenoside Rb 2 ginsenoside Rb 3 ginsenoside Re ginsenoside Rg 2 ginsenoside Rg 3 ginsenoside Rg 4 ginsenoside Rh 1 ginsenoside Rh 2 ginsenoside Rh 3 notoginsenoside R1 notoginsenoside st4 panaxadiol protopanaxadiol unclassified drug acetylcholine amyloid beta protein ginsenoside plant extract Alzheimer disease Article chemical composition cognition drug mechanism ginseng human nerve cell nervous system inflammation neurofibrillary tangle nonhuman pathogenesis Pi3K/Akt signaling Alzheimer disease animal chemistry metabolism Panax Acetylcholine Alzheimer Disease Amyloid beta-Peptides Animals Ginsenosides Humans Panax Plant Extracts
Ginseng is one of the main representatives of traditional Chinese medicine and presents a wide range of pharmacological actions. Ginsenosides are the main class of active compounds found in ginseng. They demonstrate unique biological activity and medicinal value, namely anti-tumour, anti-inflammatory and antioxidant properties, as well as anti-apoptotic properties. Increasing levels of stress in life are responsible for the increased incidence of nervous system diseases. Neurological diseases create a huge burden on the lives and health of individuals. In recent years, studies have indicated that ginsenosides play a pronounced positive role in the prevention and treatment of neurological diseases. Nevertheless, research is still at an early stage of development, and the complex mechanisms of action involved remain largely unknown. This review aimed to shed light into what is currently known about the mechanisms of action of ginsenosides in relation to Alzheimer's disease. Scientific ma