Аннотация:
The effect of solid dispersions (SDs) on the solubility of the nonsteroidal anti-inflammatory drug ketoprofen was determined. Ketoprofen and its SDs with poly(ethylene glycol) PEG-400, -1000, -1500, -2000, and -3000 were studied. Dissolution of ketoprofen from the SDs increased by 1.2 – 1.8 times; the dissolution rate, by 1.7 – 2.4 times. The improved release of ketoprofen from the SDs was proposed to be due to several factors such as solubilization and amorphization of the compound and formation of intermolecular H-bonds. The results could be used to develop rapidly dissolving ketoprofen solid dosage forms. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
Belyatskaya A. V. Anastasiya Vladimirovna 1982-
Krasnyuk I. I. Ivan Ivanovich 1979-
Krasnyuk I. I. Ivan Ivanovich 1955-
Stepanova O. I. Ol`ga Ivanovna 1988-
Kosheleva T. M. Tat`yana Mikhaylovna 1992-
Yakhyaeva S. T. Saida Telmanovna 1994-
Vorob’ev A. N.
Maryanyan M. M. Monika Mekhakovna 1997-
Беляцкая А. В. Анастасия Владимировна 1982-
Краснюк И. И. Иван Иванович 1979-
Краснюк И. И. Иван Иванович 1955-
Степанова О. И. Ольга Ивановна 1988-
Кошелева Т. М. Татьяна Михайловна 1992-
Яхяева С. Т. Саида Телмановна 1994-
Вороб’ев А. Н.
Марянян М. М. Моника Мехаковна 1997-
Dissolution of Ketoprofen from Poly(Ethylene Glycol) Solid Dispersions
Текст визуальный непосредственный
Pharmaceutical Chemistry Journal
Springer New York Consultants Bureau
Vol.52, Issue12 P. 1001-1006
2019
Статья
dissolution ketoprofen poly(ethylene glycol) solid dispersions
ketoprofen macrogol macrogol 1000 macrogol 1500 macrogol 2000 macrogol 3000 macrogol 400 unclassified drug Article dispersion drug solubility infrared spectroscopy microscopy solubilization
The effect of solid dispersions (SDs) on the solubility of the nonsteroidal anti-inflammatory drug ketoprofen was determined. Ketoprofen and its SDs with poly(ethylene glycol) PEG-400, -1000, -1500, -2000, and -3000 were studied. Dissolution of ketoprofen from the SDs increased by 1.2 – 1.8 times; the dissolution rate, by 1.7 – 2.4 times. The improved release of ketoprofen from the SDs was proposed to be due to several factors such as solubilization and amorphization of the compound and formation of intermolecular H-bonds. The results could be used to develop rapidly dissolving ketoprofen solid dosage forms. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.