Added value of diffusion-weighted MRI for nodal radiotherapy planning in pelvic malignancies
Sushentsev N., Martin H., Rimmer Y., Barrett T.
Clinical and Translational Oncology
Vol.21, Issue10, P. 1383-1389
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1007/s12094-019-02068-0
Аннотация:
Purpose: To evaluate the added value of diffusion-weighted imaging (DWI) to T2-weighted imaging (T2WI) for improved identification of pelvic lymph nodes (LN) by radiation oncologists. Methods/patients: This retrospective study included 20 patients with histopathologically proven node-negative prostate cancer. All patients underwent 3T-MRI of the prostate; matched axial T2WI and DWI sequences were assessed by an experienced uro-radiologist as the reference standard. Consultant and specialist registrar radiation oncologists were asked to identify all LN first on T2WI alone (read 1) and then on T2WI and DWI combined (read 2); LN were measured in size and divided into true positives (TP), false positives (FP) and false negatives (FN). Sensitivity, positive predictive value (PPV) and false negative rate (FNR) were then calculated and compared using Pearson’s Chi square test. Results: A total of 177 LN comprised the reference standard. 16 TP, 16 FP and 161 FN LN (sensitivity 9.0[%], PPV 50.0[%],
Ключевые слова:
Diffusion-weighted imaging; Lymph nodes; MRI; Pelvic malignancies; Prostate cancer; Radiotherapy planning
gadobutrol; adult; Article; cancer radiotherapy; clinical article; diagnostic value; diffusion weighted imaging; false negative result; false positive result; Gleason score; histopathology; human; human tissue; male; middle aged; pelvis lymph node; predictive value; prostate; prostate cancer; retrospective study; sensitivity and specificity; true positive; aged; chi square distribution; diagnostic imaging; lymph node; nuclear magnetic resonance imaging; pathology; pelvis; procedures; prostate tumor; radiation oncologist; radiotherapy; radiotherapy planning system; standard; Aged; Chi-Square Distribution; Diffusion Magnetic Resonance Imaging; False Negative Reactions; Humans; Lymph Nodes; Lymphatic Irradiation; Magnetic Resonance Imaging; Male; Middle Aged; Pelvis; Predictive Value of Tests; Prostatic Neoplasms; Radiation Oncologists; Radiotherapy Planning, Computer-Assisted; Reference Standards; Retrospective Studies; Sensitivity and Specificity
Язык текста: Английский
ISSN: 1699-3055
Sushentsev N.
Martin H.
Rimmer Y.
Barrett T.
Сушенцев Н.
Мартин Х.
Риммер Y.
Барретт Т.
Added value of diffusion-weighted MRI for nodal radiotherapy planning in pelvic malignancies
Текст визуальный непосредственный
Clinical and Translational Oncology
Doyma
Vol.21, Issue10 P. 1383-1389
2019
Статья
Diffusion-weighted imaging Lymph nodes MRI Pelvic malignancies Prostate cancer Radiotherapy planning
gadobutrol adult Article cancer radiotherapy clinical article diagnostic value diffusion weighted imaging false negative result false positive result Gleason score histopathology human human tissue male middle aged pelvis lymph node predictive value prostate prostate cancer retrospective study sensitivity and specificity true positive aged chi square distribution diagnostic imaging lymph node nuclear magnetic resonance imaging pathology pelvis procedures prostate tumor radiation oncologist radiotherapy radiotherapy planning system standard Aged Chi-Square Distribution Diffusion Magnetic Resonance Imaging False Negative Reactions Humans Lymph Nodes Lymphatic Irradiation Magnetic Resonance Imaging Male Middle Aged Pelvis Predictive Value of Tests Prostatic Neoplasms Radiation Oncologists Radiotherapy Planning, Computer-Assisted Reference Standards Retrospective Studies Sensitivity and Specificity
Purpose: To evaluate the added value of diffusion-weighted imaging (DWI) to T2-weighted imaging (T2WI) for improved identification of pelvic lymph nodes (LN) by radiation oncologists. Methods/patients: This retrospective study included 20 patients with histopathologically proven node-negative prostate cancer. All patients underwent 3T-MRI of the prostate; matched axial T2WI and DWI sequences were assessed by an experienced uro-radiologist as the reference standard. Consultant and specialist registrar radiation oncologists were asked to identify all LN first on T2WI alone (read 1) and then on T2WI and DWI combined (read 2); LN were measured in size and divided into true positives (TP), false positives (FP) and false negatives (FN). Sensitivity, positive predictive value (PPV) and false negative rate (FNR) were then calculated and compared using Pearson’s Chi square test. Results: A total of 177 LN comprised the reference standard. 16 TP, 16 FP and 161 FN LN (sensitivity 9.0[%], PPV 50.0[%],