Аннотация:
Objective. This study aimed to assess the cognitive functions and cerebral blood flow measured with arterial spin labeling (ASL) and their possible correlations with vascular age in untreated middle-aged patients with grade 1-2 essential arterial hypertension (EAH). Methods. We examined 73 subjects aged 40-59 years (33 with EAH and 40 healthy volunteers [controls]). Neuropsychological assessment included Montreal Cognitive Assessment (MoCA), Trail Making test (part A and part B), Stroop Color and Word Test, verbal fluency test (phonemic verbal fluency and semantic verbal fluency), 10-item word list learning task. All subjects underwent brain MRI. MRI protocol included ASL. Vascular age was calculated by two techniques-using Framingham Heart Study risk tables and SCORE project scales. Results. Patients with EAH had lower performance on phonemic verbal fluency test and lower mean MoCA score (29.2±1.4 vs. 28.1±1.7 points) compared to controls (13.4±3.2, p=0.002; 29.2±1.4, p=0.001, respect
Ключевые слова:
Arterial hypertension; Arterial spin labeling; Brain; Cerebral blood flow; Cognitive impairment; Magnetic resonance imaging (MRI); Middle age; Target-organ damage; Vascular age; White matter lesions
spin label; adult; brain; brain circulation; cognition; human; middle aged; nuclear magnetic resonance imaging; Adult; Brain; Cerebrovascular Circulation; Cognition; Humans; Magnetic Resonance Imaging; Middle Aged; Spin Labels
Парфенов В. А. Владимир Анатольевич 1957-
Остроумова Т. М. Татьяна Максимовна 1991-
Перепелова Е. М. Елена Михайловна 1954-
Перепелов В. А. Всеволод Андреевич 1984-
Кочетков А. И.
Остроумова О. Д. Ольга Дмитриевна 1968-
Parfenov V. A. Vladimir Anatolyevich 1957-
Ostroumova T. M. Tat`yana Maksimovna 1991-
Perepelova E. M. Elena Mikhaylovna 1954-
Perepelov V. A. Vsevolod Andreevich 1984-
Kochetkov A. I.
Ostroumova O. D. Ol`ga Dmitrievna 1968-
Brain perfusion, cognitive functions, and vascular age in middle aged patients with essential arterial hypertension
Текст визуальный непосредственный
Кардиология
Общество специалистов по сердечной недостаточности
Т. 58, Вып. 5 С. 23-31
2018
Статья
Arterial hypertension Arterial spin labeling Brain Cerebral blood flow Cognitive impairment Magnetic resonance imaging (MRI) Middle age Target-organ damage Vascular age White matter lesions
spin label adult brain brain circulation cognition human middle aged nuclear magnetic resonance imaging Adult Brain Cerebrovascular Circulation Cognition Humans Magnetic Resonance Imaging Middle Aged Spin Labels
Objective. This study aimed to assess the cognitive functions and cerebral blood flow measured with arterial spin labeling (ASL) and their possible correlations with vascular age in untreated middle-aged patients with grade 1-2 essential arterial hypertension (EAH). Methods. We examined 73 subjects aged 40-59 years (33 with EAH and 40 healthy volunteers [controls]). Neuropsychological assessment included Montreal Cognitive Assessment (MoCA), Trail Making test (part A and part B), Stroop Color and Word Test, verbal fluency test (phonemic verbal fluency and semantic verbal fluency), 10-item word list learning task. All subjects underwent brain MRI. MRI protocol included ASL. Vascular age was calculated by two techniques-using Framingham Heart Study risk tables and SCORE project scales. Results. Patients with EAH had lower performance on phonemic verbal fluency test and lower mean MoCA score (29.2±1.4 vs. 28.1±1.7 points) compared to controls (13.4±3.2, p=0.002; 29.2±1.4, p=0.001, respect