Antipsychotics: Features of undesirable adverse reactions in elderly and senile age
Остроумова О. Д., Голобородова И. В., Исаев Р. И., Pereverzev A. P.
Журнал неврологии и психиатрии им. C.C. Корсакова
Т. 119, Вып. 2, С. 105-117
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.17116/jnevro2019119021105
Аннотация:
This review summarizes and systematizes currently available literature on antipsychotics as one of the most frequently prescribed group of psychotropic drugs. Based on published data from clinical studies and meta-analyzes, the authors consider unwanted adverse reactions in patients taking antipsychotic medications. Mechanisms of development of undesirable drug reactions are discussed. Special attention is paid to those adverse reactions of antipsychotics that most often occur in old and very old age (increased risk of adverse cardiovascular and cerebrovascular events, sudden death, prolonged QTc interval, falls, fractures, orthostatic hypotension, extrapyramidal disorders, pneumonia, urinary tract infections, etc.). © 2019, Media Sphera Publishing Group. All right reserved.
Ключевые слова:
Antipsychotics; Cardiovascular events; Elderly and senile age; Falls; Fractures; Stroke; Undesirable adverse reactions
neuroleptic agent; neuroleptic agent; psychotropic agent; aged; Article; cardiovascular disease; cerebrovascular disease; extrapyramidal syndrome; falling; fracture; human; orthostatic hypotension; pneumonia; QT prolongation; QTc interval; sudden death; urinary tract infection; very elderly; Accidental Falls; Aged; Antipsychotic Agents; Humans; Psychotropic Drugs
Язык текста: Русский
ISSN: 2309-4729
Остроумова О. Д. Ольга Дмитриевна 1968-
Голобородова И. В.
Исаев Р. И.
Pereverzev A. P.
Ostroumova O. D. Ol`ga Dmitrievna 1968-
Goloborodova I. V.
Isaev R. I.
Переверзев А. П.
Antipsychotics: Features of undesirable adverse reactions in elderly and senile age
Текст визуальный непосредственный
Журнал неврологии и психиатрии им. C.C. Корсакова
Издательство Медиа Сфера
Т. 119, Вып. 2 С. 105-117
2019
Статья
Antipsychotics Cardiovascular events Elderly and senile age Falls Fractures Stroke Undesirable adverse reactions
neuroleptic agent neuroleptic agent psychotropic agent aged Article cardiovascular disease cerebrovascular disease extrapyramidal syndrome falling fracture human orthostatic hypotension pneumonia QT prolongation QTc interval sudden death urinary tract infection very elderly Accidental Falls Aged Antipsychotic Agents Humans Psychotropic Drugs
This review summarizes and systematizes currently available literature on antipsychotics as one of the most frequently prescribed group of psychotropic drugs. Based on published data from clinical studies and meta-analyzes, the authors consider unwanted adverse reactions in patients taking antipsychotic medications. Mechanisms of development of undesirable drug reactions are discussed. Special attention is paid to those adverse reactions of antipsychotics that most often occur in old and very old age (increased risk of adverse cardiovascular and cerebrovascular events, sudden death, prolonged QTc interval, falls, fractures, orthostatic hypotension, extrapyramidal disorders, pneumonia, urinary tract infections, etc.). © 2019, Media Sphera Publishing Group. All right reserved.