Аннотация:
The skin is the largest organ of the body, which meets the environment most directly. Thus, the skin is vulnerable to various damages, particularly burn injury. Skin wound healing is a serious interaction between cell types, cytokines, mediators, the neurovascular system, and matrix remodeling. Tissue regeneration technology remarkably enhances skin repair via re-epidermalization, epidermal-stromal cell interactions, angiogenesis, and inhabitation of hypertrophic scars and keloids. The success rates of skin healing for burn injuries have significantly increased with the use of various skin substitutes. In this review, we discuss skin replacement with cells, growth factors, scaffolds, or cell-seeded scaffolds for skin tissue reconstruction and also compare the high efficacy and cost-effectiveness of each therapy. We describe the essentials, achievements, and challenges of cell-based therapy in reducing scar formation and improving burn injury treatment. © 2019 The Author(s).
Shpichka A. I. Anastasiya Iosifovna 1991-
Butnaru D. V. Denis Viktorovich 1978-
Bezrukov E. A. Evgenij Alekseevich 1975-
Sukhanov R. B. Roman Borisovich 1976-
Atala A.
Burdukovskii V.
Zhang Y.
Timashev P. S. Petr Sergeevich 1978-
Шпичка А. И. Анастасия Иосифовна 1991-
Бутнару Д. В. Денис Викторович 1978-
Безруков Е. А. Евгений Алексеевич 1975-
Суханов Р. Б. Роман Борисович 1976-
Атала А.
Бурдуковскии В.
Жанг Y.
Тимашев П. С. Петр Сергеевич 1978-
Skin tissue regeneration for burn injury
Текст визуальный непосредственный
Stem Cell Research and Therapy
BioMed Central Ltd.
Vol.10, Issue1 Num.94
2019
Обзор
Burns Cell-based therapy Skin regeneration Skin substitutes Stem cells
CD200 antigen CD34 antigen CD70 antigen collagen type 1 collagen type 3 elastin endoglin epidermal growth factor fibroblast growth factor fibroblast growth factor 2 hypoxia inducible factor 1 interleukin 1beta interleukin 6 interleukin 8 matrix metalloproteinase platelet derived growth factor protein S 100 scatter factor Smad protein stromal cell derived factor 1 Thy 1 membrane glycoprotein transcription factor PAX3 transcription factor Sox transcription factor Sox9 transforming growth factor beta transforming growth factor beta2 transforming growth factor beta3 tumor necrosis factor unindexed drug vasculotropin burn cell component cell differentiation cell migration cell proliferation cell transplantation clinical effectiveness cost effectiveness analysis endothelial progenitor cell epidermal stem cell extracellular matrix fibroblast hematopoietic stem cell human induced pluripotent stem cell keratinocyte mesenchymal stem cell nonhuman
The skin is the largest organ of the body, which meets the environment most directly. Thus, the skin is vulnerable to various damages, particularly burn injury. Skin wound healing is a serious interaction between cell types, cytokines, mediators, the neurovascular system, and matrix remodeling. Tissue regeneration technology remarkably enhances skin repair via re-epidermalization, epidermal-stromal cell interactions, angiogenesis, and inhabitation of hypertrophic scars and keloids. The success rates of skin healing for burn injuries have significantly increased with the use of various skin substitutes. In this review, we discuss skin replacement with cells, growth factors, scaffolds, or cell-seeded scaffolds for skin tissue reconstruction and also compare the high efficacy and cost-effectiveness of each therapy. We describe the essentials, achievements, and challenges of cell-based therapy in reducing scar formation and improving burn injury treatment. © 2019 The Author(s).