Аннотация:
Aim. To investigate risk factors of unfavorable prognosis in patients with chronic hepatitis C (CHC), including liver cirrhosis (LC), decompensated cirrhosis, hepatocellular carcinoma (HCC), cryoglobulinemic vasculitis (CryoVas) and B-cell non-Hodgkin's lymphoma. Materials and methods. This was a retrospective study using data of 824 patients with CHC hospitalized between 2010 and 2016 in clinic named after E.M. Tareev. We used multivariate analysis including logistic regression to calculate odds ratios (ORs) for potential risk factors/predictors associated with unfavorable outcomes in patients with CHC. Results and discussion. The rate of LC, decompensated LC, HCC, serious CryoVas and B-cell lymphoma in patients with CHC was 39.1[%] (322/824), 14.0[%] (115/824), 2.8[%] (23/824), 5.2[%] (43/824) and 1.2[%] (10/824), respectively. After adjustment for sex and age the rate of LC, decompensated LC, HCC was 22.8, 8.0 and 1.5[%], respectively. Annual rate of LC in patients with CHC was 1.5[%]; in cirrhot
Ключевые слова:
B-cell lymphome; Chronic hepatitis C; Cryoglobulinemic vasculitis; Decompensation of cirrhosis; Hepatocellular carcinoma; Liver cirrhosis; Predictors; Risk factors
antivirus agent; B cell lymphoma; chronic hepatitis C; complication; cryoglobulinemia; human; liver cell carcinoma; liver cirrhosis; liver tumor; prognosis; retrospective study; risk factor; treatment failure; vasculitis; Antiviral Agents; Carcinoma, Hepatocellular; Cryoglobulinemia; Hepatitis C, Chronic; Humans; Liver Cirrhosis; Liver Neoplasms; Lymphoma, B-Cell; Prognosis; Retrospective Studies; Risk Factors; Treatment Failure; Vasculitis
Шчанитcyна С. Е.
Бурневич Э. З. Эдуард Збигневич 1972-
Никулкина Е. Н.
Филатова А. Л. Анна Львовна 1962-
Moiseev S. V. Sergej Valentinovich 1960-
Ìухин Н. А.
Shchanitcyna S. E.
Burnevich E`. Z. E`duard Zbignevich 1972-
Nikulkina E. N.
Filatova A. L. Anna L`vovna 1962-
Моисеев С. В. Сергей Валентинович 1960-
Ìukhin N. A.
Risk factors of unfavorable prognosis of chronic hepatitis C
Текст визуальный непосредственный
Терапевтический архив
Медицинское маркетинговое агентство "МедиаМедика"
Т. 91, Вып. 2 С. 59-66
2019
Статья
B-cell lymphome Chronic hepatitis C Cryoglobulinemic vasculitis Decompensation of cirrhosis Hepatocellular carcinoma Liver cirrhosis Predictors Risk factors
antivirus agent B cell lymphoma chronic hepatitis C complication cryoglobulinemia human liver cell carcinoma liver cirrhosis liver tumor prognosis retrospective study risk factor treatment failure vasculitis Antiviral Agents Carcinoma, Hepatocellular Cryoglobulinemia Hepatitis C, Chronic Humans Liver Cirrhosis Liver Neoplasms Lymphoma, B-Cell Prognosis Retrospective Studies Risk Factors Treatment Failure Vasculitis
Aim. To investigate risk factors of unfavorable prognosis in patients with chronic hepatitis C (CHC), including liver cirrhosis (LC), decompensated cirrhosis, hepatocellular carcinoma (HCC), cryoglobulinemic vasculitis (CryoVas) and B-cell non-Hodgkin's lymphoma. Materials and methods. This was a retrospective study using data of 824 patients with CHC hospitalized between 2010 and 2016 in clinic named after E.M. Tareev. We used multivariate analysis including logistic regression to calculate odds ratios (ORs) for potential risk factors/predictors associated with unfavorable outcomes in patients with CHC. Results and discussion. The rate of LC, decompensated LC, HCC, serious CryoVas and B-cell lymphoma in patients with CHC was 39.1[%] (322/824), 14.0[%] (115/824), 2.8[%] (23/824), 5.2[%] (43/824) and 1.2[%] (10/824), respectively. After adjustment for sex and age the rate of LC, decompensated LC, HCC was 22.8, 8.0 and 1.5[%], respectively. Annual rate of LC in patients with CHC was 1.5[%]; in cirrhot