Low aquaporin-2 excretion in the nephritic syndrome: An escape from the vasopressin regulating effect

Brovko M. Yu., Ly'senko L. V., Pulin A. A., Moiseev S. V., Sholomova V. I., Shhekochikhin D. Yu., Gognieva D. G., Milovanova L. Yu., Fomin V. V.

International Journal of Nephrology and Renovascular Disease

Vol.11, P. 271-277

Опубликовано: 2018

Тип ресурса: Статья

DOI:10.2147/IJNRD.S177469

Аннотация:

Purpose: Experimental studies suggest that the nephrotic syndrome is associated with “vasopressin escape”, characterized by low aquaporin-2 (AQP2) expression in the collecting duct despite high vasopressin secretion. We investigated this phenomenon in patients with the nephrotic syndrome. Patients and methods: We recruited 47 patients with proteinuric kidney disease who were distributed into the following four groups: 1) nephrotic syndrome with kidney dysfunction (n=10); 2) nephrotic syndrome with normal kidney function (n=16); 3) partial remission of nephrotic syndrome (n=10); and 4) minimal proteinuria (n=11). Nine healthy volunteers comprised a control group. Serum copeptin level (as a marker of vasopressin secretion) and urinary AQP2 were measured using ELISA. Results: Nephrotic syndrome was associated with a significant increase in serum copeptin levels compared with those in the other groups (all P<0.05). In patients with nephrotic syndrome and a partial remission of nephrotic sy

Ключевые слова:

Aquaporin-2; Copeptin; Nephrotic syndrome; Vasopressin

aquaporin 2; argipressin; copeptin; creatinine; vasopressin; adult; Article; carboxy terminal sequence; clinical article; comparative study; controlled study; creatinine blood level; disease association; enzyme linked immunosorbent assay; excretion; female; human; kidney disease; kidney function; male; nephrotic syndrome; protein blood level; protein secretion; proteinuria; urinary excretion; water retention

Язык текста: Английский

ISSN: 1178-7058

Brovko M. Yu. Mikhail Yuryevich 1984-

Ly'senko L. V. Lidiya Vladimirovna 1937-

Pulin A. A. Andrej Alekseevich 1983-

Moiseev S. V. Sergej Valentinovich 1960-

Sholomova V. I. Viktoriya Igorevna 1987-

Shhekochikhin D. Yu. Dmitrij Yuryevich 1985-

Gognieva D. G. Dar`ya Gennadievna 1990-

Milovanova L. Yu. Lyudmila Yuryevna 1973-

Fomin V. V. Viktor Viktorovich 1978-

Бровко М. Ю. Михаил Юрьевич 1984-

Лысенко Л. В. Лидия Владимировна 1937-

Пулин А. А. Андрей Алексеевич 1983-

Моисеев С. В. Сергей Валентинович 1960-

Шоломова В. И. Виктория Игоревна 1987-

Щекочихин Д. Ю. Дмитрий Юрьевич 1985-

Гогниева Д. Г. Дарья Геннадиевна 1990-

Милованова Л. Ю. Людмила Юрьевна 1973-

Фомин В. В. Виктор Викторович 1978-

Low aquaporin-2 excretion in the nephritic syndrome: An escape from the vasopressin regulating effect

Текст визуальный непосредственный

International Journal of Nephrology and Renovascular Disease

Vol.11 P. 271-277

2018

Статья

Aquaporin-2 Copeptin Nephrotic syndrome Vasopressin

aquaporin 2 argipressin copeptin creatinine vasopressin adult Article carboxy terminal sequence clinical article comparative study controlled study creatinine blood level disease association enzyme linked immunosorbent assay excretion female human kidney disease kidney function male nephrotic syndrome protein blood level protein secretion proteinuria urinary excretion water retention

Purpose: Experimental studies suggest that the nephrotic syndrome is associated with “vasopressin escape”, characterized by low aquaporin-2 (AQP2) expression in the collecting duct despite high vasopressin secretion. We investigated this phenomenon in patients with the nephrotic syndrome. Patients and methods: We recruited 47 patients with proteinuric kidney disease who were distributed into the following four groups: 1) nephrotic syndrome with kidney dysfunction (n=10); 2) nephrotic syndrome with normal kidney function (n=16); 3) partial remission of nephrotic syndrome (n=10); and 4) minimal proteinuria (n=11). Nine healthy volunteers comprised a control group. Serum copeptin level (as a marker of vasopressin secretion) and urinary AQP2 were measured using ELISA. Results: Nephrotic syndrome was associated with a significant increase in serum copeptin levels compared with those in the other groups (all P<0.05). In patients with nephrotic syndrome and a partial remission of nephrotic sy