MUC1 story: Great expectations, disappointments and the renaissance
Syrkina M. S., Vassetzky Y. S., Rubtsov M. A.
Current Medicinal Chemistry
Vol.26, Issue3, P. 554-563
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.2174/0929867324666170817151954
Аннотация:
In the course of studying human mucin MUC1, the attitude towards this molecule has been changing time and again. Initially, the list of presumable functions of MUC1 was restricted to protecting and lubricating epithelium. To date, it is assumed to play an important role in cell signaling as well as in all stages of oncogenesis, from malignant cell transformation to tumor dissemination. The story of MUC1 is full of hopes and disappointments. However, the scientific interest to MUC1 has never waned, and the more profoundly it has been investigated, the clearer its hidden potential turned to be disclosed. The therapeutic potential of mucin MUC1 has already been noted by various scientific groups at the early stages of research. Over forty years ago, the first insights into MUC1 functions became a strong ground for considering this molecule as potential target for anticancer therapy. Therefore, this direction of research has always been of particular interest and practical importance. More
Ключевые слова:
Anticancer therapy; Breast cancer; Metastasis; MUC1; Mucin glycoprotein; PEM
DNA vaccine; epitope; mucin 1; peptide vaccine; RNA; tumor antigen; antineoplastic agent; mucin 1; Article; cancer immunotherapy; carcinogenesis; cell death; cell therapy; cellular immunity; chimeric antigen receptor T-cell immunotherapy; DNA immunization; human; neoplasm; nonhuman; protein function; RNA interference; tumor rejection; vaccination; animal; drug delivery system; drug effect; physiology; Animals; Antineoplastic Agents; Drug Delivery Systems; Humans; Mucin-1
Язык текста: Английский
ISSN: 1875-533X
Syrkina M. S.
Vassetzky Y. S.
Rubtsov M. A. Mikhail Aleksandrovich 1983-
Сyркина М. С.
Вассетзкy Y. С.
Рубцов М. А. Михаил Александрович 1983-
MUC1 story: Great expectations, disappointments and the renaissance
Текст визуальный непосредственный
Current Medicinal Chemistry
Bentham Science Publishers
Vol.26, Issue3 P. 554-563
2019
Статья
Anticancer therapy Breast cancer Metastasis MUC1 Mucin glycoprotein PEM
DNA vaccine epitope mucin 1 peptide vaccine RNA tumor antigen antineoplastic agent mucin 1 Article cancer immunotherapy carcinogenesis cell death cell therapy cellular immunity chimeric antigen receptor T-cell immunotherapy DNA immunization human neoplasm nonhuman protein function RNA interference tumor rejection vaccination animal drug delivery system drug effect physiology Animals Antineoplastic Agents Drug Delivery Systems Humans Mucin-1
In the course of studying human mucin MUC1, the attitude towards this molecule has been changing time and again. Initially, the list of presumable functions of MUC1 was restricted to protecting and lubricating epithelium. To date, it is assumed to play an important role in cell signaling as well as in all stages of oncogenesis, from malignant cell transformation to tumor dissemination. The story of MUC1 is full of hopes and disappointments. However, the scientific interest to MUC1 has never waned, and the more profoundly it has been investigated, the clearer its hidden potential turned to be disclosed. The therapeutic potential of mucin MUC1 has already been noted by various scientific groups at the early stages of research. Over forty years ago, the first insights into MUC1 functions became a strong ground for considering this molecule as potential target for anticancer therapy. Therefore, this direction of research has always been of particular interest and practical importance. More