Аннотация:
Nowadays, enzymatic therapy is a very promising line of treatment for many different diseases. There is a group of disorders and conditions, caused by fibrotic and scar processes and associated with the excessive accumulation of collagen that needs to be catabolized to normalize the connective tissue content. The human body normally synthesizes special extracellular enzymes, matrix metalloproteases (MMPs) by itself. These enzymes can cleave components of extracellular matrix (ECM) and different types of collagen and thus maintain the balance of the connective tissue components. MMPs are multifunctional enzymes and are involved in a variety of organism processes. However, under pathological conditions, the function of MMPs is not sufficient, and these enzymes fail to deal with disease. Thus, medical intervention is required. Enzymatic therapy is a very effective way of treating such collagen-associated conditions. It involves the application of exogenous collagenolytic enzymes that cata
Shekhter A. B. Anatolij Borukhovich 1933-
Balakireva A. V. Anastasiya Vasilyevna 1991-
Kuznetsova N. V. Natal`ya Viktorovna 1993-
Vukolova M. N. Marina Nikolaevna 1977-
Litvitskij P. F. Petr Frantsevich 1947-
Zamyatnin A. A. Andrej Aleksandrovich 1976-
Шехтер А. Б. Анатолий Борухович 1933-
Балакирева А. В. Анастасия Васильевна 1991-
Кузнецова Н. В. Наталья Викторовна 1993-
Вуколова М. Н. Марина Николаевна 1977-
Литвицкий П. Ф. Петр Францевич 1947-
Замятнин А. А. Андрей Александрович 1976-
Collagenolytic enzymes and their applications in biomedicine
Текст визуальный непосредственный
Current Medicinal Chemistry
Bentham Science Publishers
Vol.26, Issue3 P. 487-505
2019
Статья
Clostridium histolyticum Collagen Collagen-related disorders Collagenase Collagenolytic enzymes MMPs Paralithodes camtschatica
collagen collagenase collagenolytic enzyme enzyme metalloproteinase unclassified drug collagenase matrix metalloproteinase scleroprotein adrenal cell Article biomedicine burn chronic wound Clostridium histolyticum collagen related disease crab disease elimination diseases diverse fibrous scars disorder enzyme specificity extracellular matrix fibroblast human liver cell nonhuman pancreas islet Paralithodes camtschatica sequence homology stem cell animal metabolism pH protein degradation therapy Animals Collagen Collagenases Extracellular Matrix Extracellular Matrix Proteins Humans Hydrogen-Ion Concentration Matrix Metalloproteinases Proteolysis Therapeutics
Nowadays, enzymatic therapy is a very promising line of treatment for many different diseases. There is a group of disorders and conditions, caused by fibrotic and scar processes and associated with the excessive accumulation of collagen that needs to be catabolized to normalize the connective tissue content. The human body normally synthesizes special extracellular enzymes, matrix metalloproteases (MMPs) by itself. These enzymes can cleave components of extracellular matrix (ECM) and different types of collagen and thus maintain the balance of the connective tissue components. MMPs are multifunctional enzymes and are involved in a variety of organism processes. However, under pathological conditions, the function of MMPs is not sufficient, and these enzymes fail to deal with disease. Thus, medical intervention is required. Enzymatic therapy is a very effective way of treating such collagen-associated conditions. It involves the application of exogenous collagenolytic enzymes that cata