The impact of gender on oncologic outcomes of bladder cancer
Mun D. -., Kimura S., Shariat Sh., Abufaraj M.
Current Opinion in Urology
Vol.29, Issue3, P. 279-285
Опубликовано: 2019
Тип ресурса: Обзор
DOI:10.1097/MOU.0000000000000606
Аннотация:
Purpose of reviewThe purpose of this article is to review the current literature on the impact of gender on oncologic outcomes of bladder cancer (BCa).Recent findingsWomen are more likely to experience disease recurrence, progression, and/or death across all disease states. Furthermore, women are less likely to respond to intravesical therapy for nonmuscle invasive BCa. These disparities are explained by several hypotheses such as differential exposure to environmental carcinogens, hormonal factors, and/or disease management. Additionally, it has been shown that women suffer from delays in diagnosis because of inefficiencies in healthcare delivery. On genomic analyses, women were found to be more likely to harbor basal subtypes of BCa compared with men.SummaryA steadily growing body of evidence reveals that women present with more advanced BCa and have stage-for-stage worse outcome compared with men. The underlying mechanisms for this gender difference are multifactorial. Further studi
Ключевые слова:
bladder cancer; gender disparity; hormonal factors; intravesical therapy; molecular subtype; oncologic outcomes; radical cystectomy; urothelial cancer
bladder tumor; disease exacerbation; etiology; female; genetics; human; intravesical drug administration; male; mortality; pathology; prognosis; sex factor; treatment outcome; tumor recurrence; Administration, Intravesical; Disease Progression; Female; Humans; Male; Neoplasm Recurrence, Local; Prognosis; Sex Factors; Treatment Outcome; Urinary Bladder Neoplasms
Язык текста: Английский
ISSN: 1473-6586
Mun D. -. D.-H.
Kimura S.
Shariat Sh. Sharokh 1973-
Abufaraj M.
Мун Д. -. Д.-Х.
Кимура С.
Шариат Ш. Шарох 1973-
Абуфарай М.
The impact of gender on oncologic outcomes of bladder cancer
Текст визуальный непосредственный
Current Opinion in Urology
Lippincott Williams & Wilkins
Vol.29, Issue3 P. 279-285
2019
Обзор
bladder cancer gender disparity hormonal factors intravesical therapy molecular subtype oncologic outcomes radical cystectomy urothelial cancer
bladder tumor disease exacerbation etiology female genetics human intravesical drug administration male mortality pathology prognosis sex factor treatment outcome tumor recurrence Administration, Intravesical Disease Progression Female Humans Male Neoplasm Recurrence, Local Prognosis Sex Factors Treatment Outcome Urinary Bladder Neoplasms
Purpose of reviewThe purpose of this article is to review the current literature on the impact of gender on oncologic outcomes of bladder cancer (BCa).Recent findingsWomen are more likely to experience disease recurrence, progression, and/or death across all disease states. Furthermore, women are less likely to respond to intravesical therapy for nonmuscle invasive BCa. These disparities are explained by several hypotheses such as differential exposure to environmental carcinogens, hormonal factors, and/or disease management. Additionally, it has been shown that women suffer from delays in diagnosis because of inefficiencies in healthcare delivery. On genomic analyses, women were found to be more likely to harbor basal subtypes of BCa compared with men.SummaryA steadily growing body of evidence reveals that women present with more advanced BCa and have stage-for-stage worse outcome compared with men. The underlying mechanisms for this gender difference are multifactorial. Further studi