Рациональная фармакотерапия в кардиологии
Т. 14, Вып. 3, С. 344-349
Аннотация:
Aim. To study the erythrocyte electric charge (EEC) in patients with metabolic syndrome (MS). Material and methods. 112 patients (mean age 61.4±7.2 years) with MS (average duration of MS 8.7±5.2 years) were examined. Control group consisted of healthy volunteers (n=25) of similar age. The level of EEC was detected by the method of adsorption of a positive cationic dye (cationic blue O) on the surface of the erythrocyte plasma membrane up to the complete neutralization of their negative charge, followed by photometry of the solution and calculation of the number of charges on the erythrocyte cell surface. The results of the study were processed by Statistica 10.0 software. Results. Hypertension was found in 73[%] of patients with MS, hyperglycemia - in 39[%], diabetes - in 36[%], dyslipidemia - in 80[%] of patients. The EEC in MS patients (1.59±0.05×107) was lower than this in the control group (1.65±0.03×107; p < 0.05). With MS duration more than 5 years, the EEC was significantly lower in
Ключевые слова:
Dyslipidemia; Electric charge of erythrocytes; Metabolic syndrome; Microcirculation; Obesity
adult; Article; cell membrane; cell surface; controlled study; correlation analysis; diabetes mellitus; disease duration; dyslipidemia; electric activity; electricity; erythrocyte electric charge; human; hyperglycemia; major clinical study; metabolic syndrome X; microcirculation; photometry; serodiagnosis
Подзолков В. И. Валерий Иванович 1948-
Королева Т. В. Татьяна Вениаминовна 1952-
Брагина А. Е. Анна Евгеньевна 1973-
Кудрявцева М. Г.
Брагина Г. И. Галина Ивановна 1951-
Писарев М. В. Михаил Владимирович 1976-
Podzolkov V. I. Valerij Ivanovich 1948-
Koroleva T. V. Tat`yana Veniaminovna 1952-
Bragina A. E. Anna Evgenyevna 1973-
Kudryavtseva M. G.
Bragina G. I. Galina Ivanovna 1951-
Pisarev M. V. Mikhail Vladimirovich 1976-
Relation of disturbances in the erythrocytes electrical activity with dyslipidemia in the metabolic syndrome
Текст визуальный непосредственный
Рациональная фармакотерапия в кардиологии
Столичная издательская компания
Т. 14, Вып. 3 С. 344-349
2018
Статья
Dyslipidemia Electric charge of erythrocytes Metabolic syndrome Microcirculation Obesity
adult Article cell membrane cell surface controlled study correlation analysis diabetes mellitus disease duration dyslipidemia electric activity electricity erythrocyte electric charge human hyperglycemia major clinical study metabolic syndrome X microcirculation photometry serodiagnosis
Aim. To study the erythrocyte electric charge (EEC) in patients with metabolic syndrome (MS). Material and methods. 112 patients (mean age 61.4±7.2 years) with MS (average duration of MS 8.7±5.2 years) were examined. Control group consisted of healthy volunteers (n=25) of similar age. The level of EEC was detected by the method of adsorption of a positive cationic dye (cationic blue O) on the surface of the erythrocyte plasma membrane up to the complete neutralization of their negative charge, followed by photometry of the solution and calculation of the number of charges on the erythrocyte cell surface. The results of the study were processed by Statistica 10.0 software. Results. Hypertension was found in 73[%] of patients with MS, hyperglycemia - in 39[%], diabetes - in 36[%], dyslipidemia - in 80[%] of patients. The EEC in MS patients (1.59±0.05×107) was lower than this in the control group (1.65±0.03×107; p < 0.05). With MS duration more than 5 years, the EEC was significantly lower in