Рациональная фармакотерапия в кардиологии
Т. 14, Вып. 3, С. 319-323
Аннотация:
Aim. To study the changes in the stiffness of the arterial wall, vasomotor function of the endothelium, and appearance of new cases of atrial fibrillation (AF) in patients with arterial hypertension with long-term treatment with lisinopril. Material and method. 66 hypertensive patients with cardiac sinus rhythm at the age of 48-64 years (mean age 58.4±4.2 years) were included into the study. They were randomized into 2 groups: patients of group 1 (n=35) were prescribed lisinopril or a combination of lisinopril with hydrochlorothiazide over the 5-year follow-up; patients of group 2 (control) did not receive angiotensin converting enzyme inhibitors or angiotensin II receptor blockers. The follow-up duration was from September 2010 until June 2016. It included telephone calls once every 3 months and annual clinical, instrumental and laboratory examination. The new-onset AF was identified by the 24-hour Holter ECG monitoring results and by patient symptom diaries. Results. New-onset AF was
Ключевые слова:
Atrial fibrillation; Lisinopril; Primary prevention
angiotensin receptor antagonist; dipeptidyl carboxypeptidase inhibitor; hydrochlorothiazide; lisinopril; adult; arterial stiffness; Article; atrial fibrillation; cardiovascular disease; clinical examination; controlled study; echocardiography; electrocardiography monitoring; endothelium; follow up; heart protection; Holter monitoring; human; hypertension; incidence; laboratory test; long term care; major clinical study; primary prevention; sinus rhythm; symptomatology
Подзолков В. И. Валерий Иванович 1948-
Тарзиманова А. И. Аида Ильгизовна 1978-
Гатаулин Р. Г. Радик Габдуллович 1993-
Podzolkov V. I. Valerij Ivanovich 1948-
Tarzimanova A. I. Aida Il`gizovna 1978-
Gataulin R. G. Radik Gabdullovich 1993-
Cardioprotective properties of lisinopril: New possibilities
Текст визуальный непосредственный
Рациональная фармакотерапия в кардиологии
Столичная издательская компания
Т. 14, Вып. 3 С. 319-323
2018
Статья
Atrial fibrillation Lisinopril Primary prevention
angiotensin receptor antagonist dipeptidyl carboxypeptidase inhibitor hydrochlorothiazide lisinopril adult arterial stiffness Article atrial fibrillation cardiovascular disease clinical examination controlled study echocardiography electrocardiography monitoring endothelium follow up heart protection Holter monitoring human hypertension incidence laboratory test long term care major clinical study primary prevention sinus rhythm symptomatology
Aim. To study the changes in the stiffness of the arterial wall, vasomotor function of the endothelium, and appearance of new cases of atrial fibrillation (AF) in patients with arterial hypertension with long-term treatment with lisinopril. Material and method. 66 hypertensive patients with cardiac sinus rhythm at the age of 48-64 years (mean age 58.4±4.2 years) were included into the study. They were randomized into 2 groups: patients of group 1 (n=35) were prescribed lisinopril or a combination of lisinopril with hydrochlorothiazide over the 5-year follow-up; patients of group 2 (control) did not receive angiotensin converting enzyme inhibitors or angiotensin II receptor blockers. The follow-up duration was from September 2010 until June 2016. It included telephone calls once every 3 months and annual clinical, instrumental and laboratory examination. The new-onset AF was identified by the 24-hour Holter ECG monitoring results and by patient symptom diaries. Results. New-onset AF was