Аннотация:
Despite intensive research, thromboembolism still accounts for significant maternal morbidity and mortality. We examined thrombophilia in patients with thromboembolism during pregnancy and evaluated the efficiency of antithrombotic prophylaxis in patients with thrombophilia for the prevention of recurrent thromboembolism. Sixty-eight women with a history of thromboembolism were managed during pregnancy, in light of their thrombotic history and the result of thrombophilia assessment. Group I (n=50) received prophylaxis with low molecular weight heparin (LMWH)±aspirin (50-100 mg/day) in preconception period or from the 1st trimester, during pregnancy and at least 6 weeks postpartum. Group II (n=18) received LMWH±aspirin from the II to III trimester. Thromboses were associated with pregnancy in 27 patients (39.7[%]), with systemic diseases - in nine (13.2[%]), oral contraceptives use - 22 (32.3[%]), immobilization due to surgery and/or trauma, long flight - six (8.9[%]), septic complications - tw
Ключевые слова:
Antiphospholipid syndrome; low molecular weight heparin; pregnancy; thromboembolism; thrombophilia
acetylsalicylic acid; anticoagulant agent; blood clotting factor 5 Leiden; enoxaparin; phospholipid antibody; prothrombin; acetylsalicylic acid; fibrinolytic agent; low molecular weight heparin; adult; Article; clinical assessment; clinical evaluation; clinical feature; controlled study; disease association; disease severity; family history; female; fetus wastage; first trimester pregnancy; heterozygosity; human; hyperhomocysteinemia; immobilization; major clinical study; medical history; oral contraceptive use; preeclampsia; pregnant woman; premature labor; prepregnancy care; priority journal; puerperium; recurrent disease; sepsis; solutio placentae; systemic disease; thrombogenicity; thrombophilia; thrombosis; venous thromboembolism; complication; pregnancy; pregnancy complication; retrospective study; Russian Federation; secondary prevention; thromboembolism; thrombophilia; young adult; Adult; Aspirin; Female; Fibrinolytic Agents; Heparin, Low-Molecular-Weight; Humans; Moscow; Pregn
Akin`shina S. V. Svetlana Vladimirovna 0001-
Makatsariya A. D. Aleksandr Davidovich 1944-
Bitsadze V. O. Viktoriya Omarovna 1970-
Khizroeva D. Kh. Dzhamilya Khizrievna 1973-
Khamani N. M. Nadina Moktarovna 1991-
Акиньшина С. В. Светлана Владимировна 0001-
Макацария А. Д. Александр Давидович 1944-
Бицадзе В. О. Виктория Омаровна 1970-
Хизроева Д. Х. Джамиля Хизриевна 1973-
Хамани Н. М. Надина Моктаровна 1991-
Thromboprophylaxis in pregnant women with thrombophilia and a history of thrombosis
Текст визуальный непосредственный
Journal of Perinatal Medicine
Walter de Gruyter GmbH
Vol.46, Issue8 P. 893-899
2018
Статья
Antiphospholipid syndrome low molecular weight heparin pregnancy thromboembolism thrombophilia
acetylsalicylic acid anticoagulant agent blood clotting factor 5 Leiden enoxaparin phospholipid antibody prothrombin acetylsalicylic acid fibrinolytic agent low molecular weight heparin adult Article clinical assessment clinical evaluation clinical feature controlled study disease association disease severity family history female fetus wastage first trimester pregnancy heterozygosity human hyperhomocysteinemia immobilization major clinical study medical history oral contraceptive use preeclampsia pregnant woman premature labor prepregnancy care priority journal puerperium recurrent disease sepsis solutio placentae systemic disease thrombogenicity thrombophilia thrombosis venous thromboembolism complication pregnancy pregnancy complication retrospective study Russian Federation secondary prevention thromboembolism thrombophilia young adult Adult Aspirin Female Fibrinolytic Agents Heparin, Low-Molecular-Weight Humans Moscow Pregn
Despite intensive research, thromboembolism still accounts for significant maternal morbidity and mortality. We examined thrombophilia in patients with thromboembolism during pregnancy and evaluated the efficiency of antithrombotic prophylaxis in patients with thrombophilia for the prevention of recurrent thromboembolism. Sixty-eight women with a history of thromboembolism were managed during pregnancy, in light of their thrombotic history and the result of thrombophilia assessment. Group I (n=50) received prophylaxis with low molecular weight heparin (LMWH)±aspirin (50-100 mg/day) in preconception period or from the 1st trimester, during pregnancy and at least 6 weeks postpartum. Group II (n=18) received LMWH±aspirin from the II to III trimester. Thromboses were associated with pregnancy in 27 patients (39.7[%]), with systemic diseases - in nine (13.2[%]), oral contraceptives use - 22 (32.3[%]), immobilization due to surgery and/or trauma, long flight - six (8.9[%]), septic complications - tw