Immunological methods for TB infection diagnostics in children and adolescents. Challenges and opportunities
Владимирскy М. А.
Иммунология
Т. 39, Вып. 1, С. 61-66
Опубликовано: 2018
Тип ресурса: Обзор
DOI:10.18821/0206-4952-2018-39-1-61-66
Аннотация:
The spread of a latent tuberculosis infection - 2.3 billion people - is of emergency importance for the global task of mankind - to eliminate tuberculosis as a common disease by 2035. For children, due to the limited use of the radiological diagnosis methods, the main methods today are the immunological tests for the detection of tuberculous infection. The most common used method is the tuberculin skin test (Mantoux test) due to its lack of specificity has significant drawbacks, especially in countries using mass BCG vaccination. Relatively new methods using specific recombinant MTB proteins, both in vitro tests and in new skin tests, allow to determine tuberculosis infection in latent or active form much more specifically, however, they are somewhat less sensitive, in comparison with the Mantoux test, which requires development of these methods with the introduction of new additional specific antigens. It is obvious that crucial task is the development of new methods for distinguishin
Ключевые слова:
Antibodies; Cytokines; Gene expression; Immunodiagnostics; Skin tests; TB-infection
biological marker; gamma interferon; recombinant protein; tumor necrosis factor; adolescent; antigen specificity; child; diagnostic procedure; flow cytometry; human; immunological parameters; in vitro study; intermethod comparison; latent tuberculosis; Review; sensitivity and specificity; T lymphocyte; tuberculin test; tuberculosis
Язык текста: Русский
ISSN: 0206-4952
Владимирскy М. А.
Vladimirsky M. A.
Immunological methods for TB infection diagnostics in children and adolescents. Challenges and opportunities
Текст визуальный непосредственный
Иммунология
Издательство "Медицина"
Т. 39, Вып. 1 С. 61-66
2018
Обзор
Antibodies Cytokines Gene expression Immunodiagnostics Skin tests TB-infection
biological marker gamma interferon recombinant protein tumor necrosis factor adolescent antigen specificity child diagnostic procedure flow cytometry human immunological parameters in vitro study intermethod comparison latent tuberculosis Review sensitivity and specificity T lymphocyte tuberculin test tuberculosis
The spread of a latent tuberculosis infection - 2.3 billion people - is of emergency importance for the global task of mankind - to eliminate tuberculosis as a common disease by 2035. For children, due to the limited use of the radiological diagnosis methods, the main methods today are the immunological tests for the detection of tuberculous infection. The most common used method is the tuberculin skin test (Mantoux test) due to its lack of specificity has significant drawbacks, especially in countries using mass BCG vaccination. Relatively new methods using specific recombinant MTB proteins, both in vitro tests and in new skin tests, allow to determine tuberculosis infection in latent or active form much more specifically, however, they are somewhat less sensitive, in comparison with the Mantoux test, which requires development of these methods with the introduction of new additional specific antigens. It is obvious that crucial task is the development of new methods for distinguishin