Adjuvant acetazolamide in patients with acute severe exacerbation of COPD and noninvasive ventilation
Сое А. К., Нуралиева Г. С., Авдеев С. Н., Чучалин А. Г.
Пульмонология
Т. 28, Вып. 2, С. 177-184
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.18093/0869-0189-2018-28-2-177-184
Аннотация:
The aim of the study was to investigate an efficacy of short-term treatment with acetazolamide (ACET) in patients with acute exacerbation of COPD (AECOPD) and noninvasive ventilation (NIV). Methods. This was a prospective case-control study. The study involved 20 patients. Inclusion criteria were as follows: AECOPD; pH > 7.33; PaCO2 > 48 mmHg; HCO3 - > 26 mmol/L; and treatment with NIV. Clinical characteristics, Charlson comorbidity index, APACHE II score, arterial blood gases, and serum electrolytes were recorded before inclusion. Patients were defined as cases when they had received ACET (500 mg per day) for 3 days; they were compared to a matched control group who did not receive ACET. Clinical parameters, arterial blood gases, serum electrolytes, potential adverse effects, and length of hospital stay were monitored daily. Results. No significant differences in baseline characteristics, comorbidities, or concomitant drugs used were found between the groups. Mean duration of
Ключевые слова:
Acute exacerbation of COPD; Metabolic alkalosis; Noninvasive ventilation; Respiratory failure
acetazolamide; acute disease; adjuvant therapy; APACHE; arterial gas; Article; breathing rate; case control study; Charlson Comorbidity Index; chronic obstructive lung disease; clinical article; comorbidity; controlled study; disease exacerbation; disease severity; drug efficacy; electrolyte blood level; hospitalization; human; noninvasive ventilation; prospective study; short course therapy; systolic blood pressure
Язык текста: Русский
ISSN: 0869-0189
Сое А. К.
Нуралиева Г. С.
Авдеев С. Н. Сергей Николаевич 1968-
Чучалин А. Г.
Soe A. K.
Nuralieva G. S.
Avdeev S. N. Sergej Nikolaevich 1968-
Chuchalin A. G.
Adjuvant acetazolamide in patients with acute severe exacerbation of COPD and noninvasive ventilation
Текст визуальный непосредственный
Пульмонология
Научно-практический журнал "Пульмонология"
Т. 28, Вып. 2 С. 177-184
2018
Статья
Acute exacerbation of COPD Metabolic alkalosis Noninvasive ventilation Respiratory failure
acetazolamide acute disease adjuvant therapy APACHE arterial gas Article breathing rate case control study Charlson Comorbidity Index chronic obstructive lung disease clinical article comorbidity controlled study disease exacerbation disease severity drug efficacy electrolyte blood level hospitalization human noninvasive ventilation prospective study short course therapy systolic blood pressure
The aim of the study was to investigate an efficacy of short-term treatment with acetazolamide (ACET) in patients with acute exacerbation of COPD (AECOPD) and noninvasive ventilation (NIV). Methods. This was a prospective case-control study. The study involved 20 patients. Inclusion criteria were as follows: AECOPD; pH > 7.33; PaCO2 > 48 mmHg; HCO3 - > 26 mmol/L; and treatment with NIV. Clinical characteristics, Charlson comorbidity index, APACHE II score, arterial blood gases, and serum electrolytes were recorded before inclusion. Patients were defined as cases when they had received ACET (500 mg per day) for 3 days; they were compared to a matched control group who did not receive ACET. Clinical parameters, arterial blood gases, serum electrolytes, potential adverse effects, and length of hospital stay were monitored daily. Results. No significant differences in baseline characteristics, comorbidities, or concomitant drugs used were found between the groups. Mean duration of