Clinical features of cardiac lesion in patients with generalized sarcoidosis

Попова Е. Н., Стрижаков Л. А., Шоломова В. И., Пономарев А. Б., Моисеев С. В., Бровко М. Ю., Бондаренко И. Б., Пономарева Л. А., Фомин В. В.

Терапевтический архив

Т. 90, Вып. 1, С. 54-59

Опубликовано: 2018

Тип ресурса: Статья

DOI:10.17116/terarkh201890154-59

Аннотация:

The article presents a clinical observation of two patients with generalized sarcoidosis. The woman typical granulomatous changes in the lungs and lymph nodes combined with atrial fibrillation, kidney failure and hereditary thrombophilia, men with atherosclerotic coronary arteries, re-myocardial infarction, cholestasis, tubulointerstitial nephritis. The accession of systemic manifestations was accompanied by increase of level of angiotensin-converting enzyme in the blood serum, morphological examination of lung tissue in both cases there were high histological activity of vasculitis and granulomatous inflammation. Extrapulmonary symptoms regressed when conducting immuno-suppressive therapy. Discusses modern aspects of diagnosis of sarcoidosis in clinical practice. © 2018 Media Sphera Publishing Group. All rights reserved.

Ключевые слова:

Atherosclerosis; Cardiac rhythm disorder; Cardiomyopathy; Extrapulmonary manifestation of sarcoidosis; Sarcoidosis

glucocorticoid; atrial fibrillation; case report; complication; female; human; interstitial nephritis; lymph node; male; sarcoidosis; vasculitis; Atrial Fibrillation; Female; Glucocorticoids; Humans; Lymph Nodes; Male; Nephritis, Interstitial; Sarcoidosis; Vasculitis

Язык текста: Русский

ISSN: 2309-5342

Попова Е. Н. Елена Николаевна 1969-

Стрижаков Л. А. Леонид Александрович 1976-

Шоломова В. И. Виктория Игоревна 1987-

Пономарев А. Б. Андрей Борисович 1962-

Моисеев С. В. Сергей Валентинович 1960-

Бровко М. Ю. Михаил Юрьевич 1984-

Бондаренко И. Б. Инна Борисовна 1968-

Пономарева Л. А. Любовь Андреевна 1997-

Фомин В. В. Виктор Викторович 1978-

Popova E. N. Elena Nikolaevna 1969-

Strizhakov L. A. Leonid Aleksandrovich 1976-

Sholomova V. I. Viktoriya Igorevna 1987-

Ponomarev A. B. Andrej Borisovich 1962-

Moiseev S. V. Sergej Valentinovich 1960-

Brovko M. Yu. Mikhail Yuryevich 1984-

Bondarenko I. B. Inna Borisovna 1968-

Ponomareva L. A. Lyubov` Andreevna 1997-

Fomin V. V. Viktor Viktorovich 1978-

Clinical features of cardiac lesion in patients with generalized sarcoidosis

Текст визуальный непосредственный

Терапевтический архив

Медицинское маркетинговое агентство "МедиаМедика"

Т. 90, Вып. 1 С. 54-59

2018

Статья

Atherosclerosis Cardiac rhythm disorder Cardiomyopathy Extrapulmonary manifestation of sarcoidosis Sarcoidosis

glucocorticoid atrial fibrillation case report complication female human interstitial nephritis lymph node male sarcoidosis vasculitis Atrial Fibrillation Female Glucocorticoids Humans Lymph Nodes Male Nephritis, Interstitial Sarcoidosis Vasculitis

The article presents a clinical observation of two patients with generalized sarcoidosis. The woman typical granulomatous changes in the lungs and lymph nodes combined with atrial fibrillation, kidney failure and hereditary thrombophilia, men with atherosclerotic coronary arteries, re-myocardial infarction, cholestasis, tubulointerstitial nephritis. The accession of systemic manifestations was accompanied by increase of level of angiotensin-converting enzyme in the blood serum, morphological examination of lung tissue in both cases there were high histological activity of vasculitis and granulomatous inflammation. Extrapulmonary symptoms regressed when conducting immuno-suppressive therapy. Discusses modern aspects of diagnosis of sarcoidosis in clinical practice. © 2018 Media Sphera Publishing Group. All rights reserved.