Размер шрифта
Цветовая схема
Изображения
Форма
Межсимвольный интервал
Межстрочный интервал
стандартные настройки
обычная версия сайта
закрыть
  • Вход
  • Регистрация
  • Помощь
Выбрать БД
Простой поискРасширенный поискИстория поисков
Главная / Результаты поиска

Role of mesenchymal multipotent stromal cells in remodeling of bone defects

Киселевскy М. В., Анисимова Н. Y., Должикова Y. И., Власенко Р. Y., Сенатов Ф. С., Караулов А. В.
Медицинская иммунология
Т. 20, Вып. 4, С. 515-522
Опубликовано: 2018
Тип ресурса: Обзор

DOI:10.15789/1563-0625-2018-4-515-522

Аннотация:
Ability of mesenchymal multipotent stromal cells (MSCs) to differentiate into several types of mesenchymal tissues allows to consider these cells the main candidates for creating tissue engineering constructions for regenerative medicine. MSCs promote integration of bio-implants into the native bone and stimulate osteogenesis. MSCs are characterized by immunomodulatory properties, due to inflammation control and modification of immune cells. MSCs affect not only the in vivo immune response by preventing immunological rejection of implanted tissue engineering designs, but it can also influence the bone tissue immunity. MSCs play an important role in bone regeneration, by regulating the osteoblastic generation, and suppressing activity of inflammation effectors and osteoclastogenesis. Some pre-clinical and first clinical trials of bone bio-implants colonized with MSC, demonstrate promising outlooks for this strategy in order to obtain tissue engineering constructions for bone regeneratio
Ключевые слова:
Bone bioimplants; Immunomodulating activity; Mesenchymal multipotent stromal cells; Osteoimmunology; Tissue engineering constructions
Язык текста: Русский
ISSN: 2313-741X
Киселевскy М. В.
Анисимова Н. Y. Н.Ю.
Должикова Y. И. Ю.И.
Власенко Р. Y. Р.Я.
Сенатов Ф. С.
Караулов А. В. Александр Викторович 1953-
Kiselevsky M. V.
Anisimova N. Y. N.Yu.
Dolzhikova Y. I. Yu.I.
Vlasenko R. Y. R.Ya.
Senatov F. S.
Karaulov A. V. Aleksandr Viktorovich 1953-
Role of mesenchymal multipotent stromal cells in remodeling of bone defects
Текст визуальный непосредственный
Медицинская иммунология
Санкт-Петербургское региональное отделение Российской ассоциации аллергологов и клинических иммунологов
Т. 20, Вып. 4 С. 515-522
2018
Обзор
Bone bioimplants Immunomodulating activity Mesenchymal multipotent stromal cells Osteoimmunology Tissue engineering constructions
Ability of mesenchymal multipotent stromal cells (MSCs) to differentiate into several types of mesenchymal tissues allows to consider these cells the main candidates for creating tissue engineering constructions for regenerative medicine. MSCs promote integration of bio-implants into the native bone and stimulate osteogenesis. MSCs are characterized by immunomodulatory properties, due to inflammation control and modification of immune cells. MSCs affect not only the in vivo immune response by preventing immunological rejection of implanted tissue engineering designs, but it can also influence the bone tissue immunity. MSCs play an important role in bone regeneration, by regulating the osteoblastic generation, and suppressing activity of inflammation effectors and osteoclastogenesis. Some pre-clinical and first clinical trials of bone bio-implants colonized with MSC, demonstrate promising outlooks for this strategy in order to obtain tissue engineering constructions for bone regeneratio