Аннотация:
The review considers modern ideas about the clinic and pathogenesis of minimal hepatic encephalopathy (MHE). It is discussed the present of cognitive impairment in this category of patients. The data of functional MRI are analyzed, and these results allow taking a fresh look at the origin of clinical disorders in this condition. The importance of cerebral connections disruption is emphasized. It is focused on the fact that in the functioning of the central nervous system the spontaneous activity of the brain has a significant importance. Separately is analyzed "the resting state". It is concluded that MHE, despite its minimal manifestations, is a clinically significant condition requiring attention of a specialists. With that, it is often not diagnosed on time in clinical practice, which could lead to more severe damage of the cerebral functions. As evidenced by the data obtained at the present time, quite extensive changes in the neuronal activity are underlid of the cognitive deficit
Ключевые слова:
Clinical features; Functional brain imaging.; Minimal hepatic encephalopathy; Pathogenesis; Resting state activity of the brain
brain; cognitive defect; complication; diagnostic imaging; hepatic encephalopathy; human; nuclear magnetic resonance imaging; pathology; Brain; Cognition Disorders; Hepatic Encephalopathy; Humans; Magnetic Resonance Imaging
Дамулин И. В.
Damulin I. V.
Minimal hepatic encephalopathy: Current clinical and pathogenetic aspects
Текст визуальный непосредственный
Терапевтический архив
Медицинское маркетинговое агентство "МедиаМедика"
Т. 90, Вып. 2 С. 89-93
2018
Статья
Clinical features Functional brain imaging. Minimal hepatic encephalopathy Pathogenesis Resting state activity of the brain
brain cognitive defect complication diagnostic imaging hepatic encephalopathy human nuclear magnetic resonance imaging pathology Brain Cognition Disorders Hepatic Encephalopathy Humans Magnetic Resonance Imaging
The review considers modern ideas about the clinic and pathogenesis of minimal hepatic encephalopathy (MHE). It is discussed the present of cognitive impairment in this category of patients. The data of functional MRI are analyzed, and these results allow taking a fresh look at the origin of clinical disorders in this condition. The importance of cerebral connections disruption is emphasized. It is focused on the fact that in the functioning of the central nervous system the spontaneous activity of the brain has a significant importance. Separately is analyzed "the resting state". It is concluded that MHE, despite its minimal manifestations, is a clinically significant condition requiring attention of a specialists. With that, it is often not diagnosed on time in clinical practice, which could lead to more severe damage of the cerebral functions. As evidenced by the data obtained at the present time, quite extensive changes in the neuronal activity are underlid of the cognitive deficit