Аннотация:
The results of a clinical study showing the importance of surfactant proteins A and D in assessing the activity and progression of idiopathic pulmonary fibrosis and chronic lung sarcoidosis are presented. Aim. To study the clinical significance of SP-A, SP-D in assessing the activity of idiopathic pulmonary fibrosis and sarcoidosis. We examined 81 patients with morphologically confirmed diagnoses of idiopathic pulmonary fibrosis (ILF) and sarcoidosis, a control group of 20 healthy individuals. The MSCT of the thoracic organs of the chest was performed, the diffusivity of the lungs was examined, oxygen saturation was determined. In the serum, the surfactant proteins SP-A and SP-D were determined by the enzyme-linked immunosorbent assay. Results. A significant increase in SP-A and SP-D (p<0.05) was observed in patients compared with patients in the control group, a direct correlation was found with signs of activity: SP-A with alveolitis (p<0.05), SP- D with progressive fibrosis (p<0.05)
Бекетов В. Д.
Лебедева М. В. Марина Валерьевна 1966-
Мухин Н. А. Николай Алексеевич 1936-
Серова А. Г. Анна Григорьевна 1962-
Пономарев А. Б. Андрей Борисович 1962-
Попова Е. Н. Елена Николаевна 1969-
Янакаева А. С. А.Ш.
Соломка В. А. Вячеслав Алексеевич 1994-
Кондрашов А. В. Алексей Викторович 1994-
Коновалов Д. В. Денис Владимирович 1977-
Beketov V. D.
Lebedeva M. V. Marina Valeryevna 1966-
Mukhin N. A. Nikolay Alekseevich 1936-
Serova A. G. Anna Grigoryevna 1962-
Ponomarev A. B. Andrej Borisovich 1962-
Popova E. N. Elena Nikolaevna 1969-
Yanakaeva A. S. A.Sh.
Solomka V. A. Vyacheslav Alekseevich 1994-
Kondrashov A. V. Aleksej Viktorovich 1994-
Konovalov D. V. Denis Vladimirovich 1977-
Clinical significance of the determination of surfactant proteins A and D in assessing the activity of lung sarcoidosis
Текст визуальный непосредственный
Терапевтический архив
Медицинское маркетинговое агентство "МедиаМедика"
Т. 90, Вып. 3 С. 42-46
2018
Статья
Interstitial lung diseases Pulmonary fibrosis Sarcoidosis Surfactant protein A Surfactant protein D
biological marker surfactant surfactant protein A surfactant protein D blood disease exacerbation enzyme linked immunosorbent assay human lung sarcoidosis Biomarkers Disease Progression Enzyme-Linked Immunosorbent Assay Humans Pulmonary Surfactant-Associated Protein A Pulmonary Surfactant-Associated Protein D Sarcoidosis, Pulmonary Surface-Active Agents
The results of a clinical study showing the importance of surfactant proteins A and D in assessing the activity and progression of idiopathic pulmonary fibrosis and chronic lung sarcoidosis are presented. Aim. To study the clinical significance of SP-A, SP-D in assessing the activity of idiopathic pulmonary fibrosis and sarcoidosis. We examined 81 patients with morphologically confirmed diagnoses of idiopathic pulmonary fibrosis (ILF) and sarcoidosis, a control group of 20 healthy individuals. The MSCT of the thoracic organs of the chest was performed, the diffusivity of the lungs was examined, oxygen saturation was determined. In the serum, the surfactant proteins SP-A and SP-D were determined by the enzyme-linked immunosorbent assay. Results. A significant increase in SP-A and SP-D (p<0.05) was observed in patients compared with patients in the control group, a direct correlation was found with signs of activity: SP-A with alveolitis (p<0.05), SP- D with progressive fibrosis (p<0.05)