Аннотация:
Serotonin (5-HT) is involved in sleep in two different ways. First, when released during waking by the axonal nerve endings, it influences the synthesis of hypnogenic substances in specific brain targets. Such a synthesis might be in keeping with the waking qualitative aspects. As an example, the hypnogenic CLIP peptide (ACTH18-39) is synthesized when stressful events occur during wakefulness. Second, when released during sleep within the nucleus raphe dorsalis (nRD) by dendrites of 5-HT neurons, it contributes to 5-HT perikarya silencing through an auto-inhibitory process. Nitric oxide, co-synthesized with 5-HT, may act in synergy with this amine at both mentioned levels. Regarding the triggered hypnogenic substances, they induce sleep through acting on two components within the nRD: (1) the 5-HT component; its silencing is necessary to remove the gating effect exerted on phasic sleep events (ponto-geniculo-occipital, PGO, waves); (2) a substance P component; its silencing is necessar
Ключевые слова:
Cat - rat; Hypnogenic substances; n. raphe dorsalis; Serotonin; Substance P
corticotropin[18-39]; nitric oxide; serotonin; substance P; corticotropin[18-39]; peptide; serotonin; Article; axon; biosynthesis; brain region; dendrite; dorsal raphe nucleus; human; insomnia; muscle; nerve ending; nonhuman; peptide synthesis; perikaryon; pontogeniculooccipital wave; priority journal; serotonin release; serotoninergic nerve cell; sleep; stress; wakefulness; animal; cat; drug effect; France; history; metabolism; physiology; raphe nucleus; REM sleep; research; sleep; sleep stage; Animals; Cats; Corticotropin-Like Intermediate Lobe Peptide; France; History, 20th Century; History, 21st Century; Humans; Peptides; Raphe Nuclei; Research; Serotonin; Sleep; Sleep Initiation and Maintenance Disorders; Sleep Stages; Sleep, REM
Cespuglio R.
Cеспуглио Р.
Serotonin: its place today in sleep preparation, triggering or maintenance
Текст визуальный непосредственный
Sleep Medicine
Elsevier Science Publisher B.V.
Vol.49 P. 31-39
2018
Статья
Cat - rat Hypnogenic substances n. raphe dorsalis Serotonin Substance P
corticotropin[18-39] nitric oxide serotonin substance P corticotropin[18-39] peptide serotonin Article axon biosynthesis brain region dendrite dorsal raphe nucleus human insomnia muscle nerve ending nonhuman peptide synthesis perikaryon pontogeniculooccipital wave priority journal serotonin release serotoninergic nerve cell sleep stress wakefulness animal cat drug effect France history metabolism physiology raphe nucleus REM sleep research sleep sleep stage Animals Cats Corticotropin-Like Intermediate Lobe Peptide France History, 20th Century History, 21st Century Humans Peptides Raphe Nuclei Research Serotonin Sleep Sleep Initiation and Maintenance Disorders Sleep Stages Sleep, REM
Serotonin (5-HT) is involved in sleep in two different ways. First, when released during waking by the axonal nerve endings, it influences the synthesis of hypnogenic substances in specific brain targets. Such a synthesis might be in keeping with the waking qualitative aspects. As an example, the hypnogenic CLIP peptide (ACTH18-39) is synthesized when stressful events occur during wakefulness. Second, when released during sleep within the nucleus raphe dorsalis (nRD) by dendrites of 5-HT neurons, it contributes to 5-HT perikarya silencing through an auto-inhibitory process. Nitric oxide, co-synthesized with 5-HT, may act in synergy with this amine at both mentioned levels. Regarding the triggered hypnogenic substances, they induce sleep through acting on two components within the nRD: (1) the 5-HT component; its silencing is necessary to remove the gating effect exerted on phasic sleep events (ponto-geniculo-occipital, PGO, waves); (2) a substance P component; its silencing is necessar