Granulation of Effervescent Ingredients for Optimization of Gastroretentive Properties of Floating Proroxan Prolonged-Release Tablets
Nifontova G. O., Krechetov S. P., Dolotova O. V., Buyukli S. R., Akhmetzyanova A. R., Krasnyuk I. I.
Pharmaceutical Chemistry Journal
Vol.52, Issue4, P. 361-365
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.1007/s11094-018-1822-5
Аннотация:
Research results supporting the manufacturing technology for floating prolonged-release oral tablets based on a hydrophilic matrix with the nonselective α-adrenoblocker proroxan are presented.Wet granulation of the effervescent ingredients with the matrix produced tablets with the required buoyancy lag-time, float time, and proroxan release kinetics. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.
Ключевые слова:
gastroretentive properties; hydrophilic matrix; prolonged release; proroxan; wet granulation
proroxan; Article; drug granulation; drug release; drug solubility; effervescent tablet; floating prolonged drug release; hydrophilicity; kinetics; nuclear magnetic resonance imaging; tablet formulation
Язык текста: Английский
ISSN: 1573-9031
Nifontova G. O. Galina Olegovna 1991-
Krechetov S. P.
Dolotova O. V.
Buyukli S. R.
Akhmetzyanova A. R.
Krasnyuk I. I. Ivan Ivanovich 1955-
Нифонтова Г. О. Галина Олеговна 1991-
Кречетов С. П.
Долотова О. В.
Буюкли С. Р.
Ахметзянова А. Р.
Краснюк И. И. Иван Иванович 1955-
Granulation of Effervescent Ingredients for Optimization of Gastroretentive Properties of Floating Proroxan Prolonged-Release Tablets
Текст визуальный непосредственный
Pharmaceutical Chemistry Journal
Springer New York Consultants Bureau
Vol.52, Issue4 P. 361-365
2018
Статья
gastroretentive properties hydrophilic matrix prolonged release proroxan wet granulation
proroxan Article drug granulation drug release drug solubility effervescent tablet floating prolonged drug release hydrophilicity kinetics nuclear magnetic resonance imaging tablet formulation
Research results supporting the manufacturing technology for floating prolonged-release oral tablets based on a hydrophilic matrix with the nonselective α-adrenoblocker proroxan are presented.Wet granulation of the effervescent ingredients with the matrix produced tablets with the required buoyancy lag-time, float time, and proroxan release kinetics. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.