Аннотация:
The exact cause of the development of anxiety disorders (AD) in present time has not been fully established and is a subject of debate in many countries. Interest in studying the mechanisms of action of proteins of S100 group, in particular, neurospecific protein S100b, is caused by its participation in processes of integrative activity of brain/neuron and development of diseases of nervous system. The functions of S100 proteins determine their influence on synaptic plasticity and participation in the regulation of stress-realizing and stress-limiting systems, the imbalance of which (primarily, the insufficiency of the GABA-ergic system) is the neurobiological basis of the majority of anxiety-depressive pathologies. Preparations regulating the activity of S100 protein have a distinct clinical anti-anxiety effect and additionally contribute to the restoration of neuronal plasticity processes. © 2018 Media Sphera Publishing Group. All rights reserved.
Ключевые слова:
Anxiety disorders; Failure of the gaba-ergic system; S100 proteins; Synaptic plasticity
anxiolytic agent; protein S 100; anxiety; anxiety disorder; comorbidity; complication; drug effect; human; metabolism; nerve cell plasticity; Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Comorbidity; Humans; Neuronal Plasticity; S100 Proteins
Шавловская О. А. Ольга Александровна 1970-
Кузнецов С. Л. Сергей Львович 1951-
Shavlovskaya O. A. Ol`ga Aleksandrovna 1970-
Kuznetsov S. L. Sergej L`vovich 1951-
Correction of anxiety disorders: Focus on a comorbid patient
Текст визуальный непосредственный
Терапевтический архив
Медицинское маркетинговое агентство "МедиаМедика"
Т. 90, Вып. 4 С. 67-71
2018
Статья
Anxiety disorders Failure of the gaba-ergic system S100 proteins Synaptic plasticity
anxiolytic agent protein S 100 anxiety anxiety disorder comorbidity complication drug effect human metabolism nerve cell plasticity Anti-Anxiety Agents Anxiety Anxiety Disorders Comorbidity Humans Neuronal Plasticity S100 Proteins
The exact cause of the development of anxiety disorders (AD) in present time has not been fully established and is a subject of debate in many countries. Interest in studying the mechanisms of action of proteins of S100 group, in particular, neurospecific protein S100b, is caused by its participation in processes of integrative activity of brain/neuron and development of diseases of nervous system. The functions of S100 proteins determine their influence on synaptic plasticity and participation in the regulation of stress-realizing and stress-limiting systems, the imbalance of which (primarily, the insufficiency of the GABA-ergic system) is the neurobiological basis of the majority of anxiety-depressive pathologies. Preparations regulating the activity of S100 protein have a distinct clinical anti-anxiety effect and additionally contribute to the restoration of neuronal plasticity processes. © 2018 Media Sphera Publishing Group. All rights reserved.