Association of polymorphisms of HLA-DRB1 and TNF-308 G/A with radiographic joint damage in patients with early rheumatoid arthritis with high...
Гусева И. А., Смирнов А. В., Демидова Н. В., Крyлов М. Y., Авдеева А. С., Самаркина Е. Y., Лучихина Е. Л., Каратеев Д. Е., Абрамов Д. Д., Насонов Е. Л.
Терапевтический архив
Т. 90, Вып. 5, С. 38-43
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.26442/terarkh201890538-43
Аннотация:
Objective. To clarify the association between HLA-DRB1 and TNFα (-308G>A) genes polymorphism and joint destruction/further progression during 12 months of the follow-up period (FUP) in patients with early (<6 months), active, predominantly antibodies to cyclic citrullinated peptide (ACCP) and rheumatoid factor (RF)-positive rheumatoid arthritis (RA) treated according to "Treat to target" strategy. Materials and Methods. The study included 85 patients with early RA and duration of symptoms <6 months. All patients were initially assigned to subcutaneous methotrexate (MTX) with rapid dose escalation to 20-25 mg/week. Combination MTX + biological therapy, mainly adalimumab, was used when MTX was ineffective. Joint destruction was assessed by Sharp-Van der Heijde modification scoring method at baseline and after 12 months FUP. Real time polymerase chain reaction (PCR-RT) was used for TNFα gene polymorphism (-308G>A) genotyping. Low resolution PCR-RT with subsequent sequence-based typing of
Ключевые слова:
Disease activity; Early rheumatoid arthritis; HLA-DRB1; Radiographic damage; SE; Shared epitope; Single nucleotide polymorphism; TNFA
HLA DRB1 antigen; tumor necrosis factor; allele; disease exacerbation; genetic polymorphism; genetic predisposition; genetics; genotype; human; joint; pathology; rheumatoid arthritis; Alleles; Arthritis, Rheumatoid; Disease Progression; Genetic Predisposition to Disease; Genotype; HLA-DRB1 Chains; Humans; Joints; Polymorphism, Genetic; Tumor Necrosis Factor-alpha
Язык текста: Русский
ISSN: 2309-5342
Гусева И. А.
Смирнов А. В.
Демидова Н. В.
Крyлов М. Y. М.Ю.
Авдеева А. С.
Самаркина Е. Y. Е.Ю.
Лучихина Е. Л.
Каратеев Д. Е.
Абрамов Д. Д. Дмитрий Денисович 2002-
Насонов Е. Л. Евгений Львович 1948-
Guseva I. A.
Smirnov A. V.
Demidova N. V.
Krylov M. Y. M.Yu.
Avdeeva A. S.
Samarkina E. Y. E.Yu.
Luchikhina E. L.
Karateev D. E.
Abramov D. D. Dmitrij Denisovich 2002-
Nasonov E. L. Evgenij L`vovich 1948-
Association of polymorphisms of HLA-DRB1 and TNF-308 G/A with radiographic joint damage in patients with early rheumatoid arthritis with high inflammatory activity, treated according to the principle of "Treat to target" (REMARKA study)
Association of polymorphisms of HLA-DRB1 and TNF-308 G/A with radiographic joint damage in patients with early rheumatoid arthritis with high...
Текст визуальный непосредственный
Терапевтический архив
Медицинское маркетинговое агентство "МедиаМедика"
Т. 90, Вып. 5 С. 38-43
2018
Статья
Disease activity Early rheumatoid arthritis HLA-DRB1 Radiographic damage SE Shared epitope Single nucleotide polymorphism TNFA
HLA DRB1 antigen tumor necrosis factor allele disease exacerbation genetic polymorphism genetic predisposition genetics genotype human joint pathology rheumatoid arthritis Alleles Arthritis, Rheumatoid Disease Progression Genetic Predisposition to Disease Genotype HLA-DRB1 Chains Humans Joints Polymorphism, Genetic Tumor Necrosis Factor-alpha
Objective. To clarify the association between HLA-DRB1 and TNFα (-308G>A) genes polymorphism and joint destruction/further progression during 12 months of the follow-up period (FUP) in patients with early (<6 months), active, predominantly antibodies to cyclic citrullinated peptide (ACCP) and rheumatoid factor (RF)-positive rheumatoid arthritis (RA) treated according to "Treat to target" strategy. Materials and Methods. The study included 85 patients with early RA and duration of symptoms <6 months. All patients were initially assigned to subcutaneous methotrexate (MTX) with rapid dose escalation to 20-25 mg/week. Combination MTX + biological therapy, mainly adalimumab, was used when MTX was ineffective. Joint destruction was assessed by Sharp-Van der Heijde modification scoring method at baseline and after 12 months FUP. Real time polymerase chain reaction (PCR-RT) was used for TNFα gene polymorphism (-308G>A) genotyping. Low resolution PCR-RT with subsequent sequence-based typing of