Genetic determinants of the development and course of membranous nephropathy
Камышова Е. С., Бобкова И. Н., Горелова И. А., Êàхсуруева П. А., Филатова Е. Е.
Терапевтический архив
Т. 90, Вып. 6, С. 105-111
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.26442/terarkh2018906105-111
Аннотация:
Membranous nephropathy (MN) is one of the most common causes of nephrotic syndrome in adults and is classified as either primary (idiopatic) or secondary MN according to underlying etiology (the later result from some known disease such as systemic autoimmune diseases, infections, malignancies, drugs, etc). In recent years, phospholipase A2 receptor 1 (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A) were identified as two major podocytic antigens involved in the pathogenesis of idiopatic MN (IMN). And the discovery of circulating antibodies specific for these target antigens has transformed the diagnostic workup and significally improved management of IMN. However why do such antibodies develop is not conclusively established. The role of underlying genetic factors is discussed. The review presents the results of recent studies, that have shown significant associations of specific genetic factors (particularly human leucocyte antigen class II and PLA2R1 genes) with IMN.
Ключевые слова:
Gene; Human leukocyte antigens (HLA); Idiopathic membranous nephropathy; MPC class II; Phospholipase A2 receptor (PLA2R); PLA2R1
antigen; autoantibody; phospholipase A2 receptor; PLA2R1 protein, human; thrombospondin; adult; genetics; human; immunology; membranous glomerulonephritis; microbiology; nephrotic syndrome; Adult; Antigens; Autoantibodies; Glomerulonephritis, Membranous; Humans; Nephrotic Syndrome; Receptors, Phospholipase A2; Thrombospondins
Язык текста: Русский
ISSN: 2309-5342
Камышова Е. С. Елена Сергеевна 1976-
Бобкова И. Н. Ирина Николаевна 1967-
Горелова И. А.
Êàхсуруева П. А.
Филатова Е. Е.
Kamy'shova E. S. Elena Sergeevna 1976-
Bobkova I. N. Irina Nikolaevna 1967-
Gorelova I. A.
Êàkhsurueva P. A.
Filatova E. E.
Genetic determinants of the development and course of membranous nephropathy
Текст визуальный непосредственный
Терапевтический архив
Медицинское маркетинговое агентство "МедиаМедика"
Т. 90, Вып. 6 С. 105-111
2018
Статья
Gene Human leukocyte antigens (HLA) Idiopathic membranous nephropathy MPC class II Phospholipase A2 receptor (PLA2R) PLA2R1
antigen autoantibody phospholipase A2 receptor PLA2R1 protein, human thrombospondin adult genetics human immunology membranous glomerulonephritis microbiology nephrotic syndrome Adult Antigens Autoantibodies Glomerulonephritis, Membranous Humans Nephrotic Syndrome Receptors, Phospholipase A2 Thrombospondins
Membranous nephropathy (MN) is one of the most common causes of nephrotic syndrome in adults and is classified as either primary (idiopatic) or secondary MN according to underlying etiology (the later result from some known disease such as systemic autoimmune diseases, infections, malignancies, drugs, etc). In recent years, phospholipase A2 receptor 1 (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A) were identified as two major podocytic antigens involved in the pathogenesis of idiopatic MN (IMN). And the discovery of circulating antibodies specific for these target antigens has transformed the diagnostic workup and significally improved management of IMN. However why do such antibodies develop is not conclusively established. The role of underlying genetic factors is discussed. The review presents the results of recent studies, that have shown significant associations of specific genetic factors (particularly human leucocyte antigen class II and PLA2R1 genes) with IMN.