Аннотация:
Obesity, including morbid obesity, is a growing worldwide problem. The adverse effect of obesity on the kidneys is associated with the development of comorbid conditions, such as insulin resistance (IR), metabolic syndrome (MS), diabetes mellitus (DM), arterial hypertension (AH), which are the recognized risk factors of chronic kidney disease (ÑKD). Obesity also causes direct kidney damage with the development of non-immune focal segmental glomerulosclerosis. The leading pathophysiological mechanisms of kidney damage in obesity are intrarenal hemodynamic disorders with the formation of hyperfiltration and damaging effects of adipokines produced by adipose tissue. Bariatric surgery (BS) has taken a leading position in the treatment of morbid obesity, demonstrating its effectiveness not only in long-term weight loss, but also in the correction of IR, MS, DM, AH. Nephroprotective effect of significant and persistent weight loss is caused by the elimination of hyperfiltration and damaging
Ключевые слова:
Albuminuria; Bariatric surgery; Chronic kidney disease; Glomerular filtration rate; Hyperfiltration; Morbid obesity; Proteinuria
bariatric surgery; body weight loss; glomerulus filtration rate; human; kidney disease; morbid obesity; obesity; observational study; prospective study; Bariatric Surgery; Glomerular Filtration Rate; Humans; Kidney Diseases; Obesity; Obesity, Morbid; Observational Studies as Topic; Prospective Studies; Weight Loss
Бобкова И. Н. Ирина Николаевна 1967-
Гуссаова С. С. Соня Сосланбековна 1992-
Ставровская Е. В. Екатерина Викторовна 1970-
Струве А. В. Андрей Викторович 1996-
Bobkova I. N. Irina Nikolaevna 1967-
Gussaova S. S. Sonya Soslanbekovna 1992-
Stavrovskaya E. V. Ekaterina Viktorovna 1970-
Struve A. V. Andrej Viktorovich 1996-
Nephrological aspects of surgical weight correction in morbid obesity
Текст визуальный непосредственный
Терапевтический архив
Медицинское маркетинговое агентство "МедиаМедика"
Т. 90, Вып. 6 С. 98-104
2018
Статья
Albuminuria Bariatric surgery Chronic kidney disease Glomerular filtration rate Hyperfiltration Morbid obesity Proteinuria
bariatric surgery body weight loss glomerulus filtration rate human kidney disease morbid obesity obesity observational study prospective study Bariatric Surgery Glomerular Filtration Rate Humans Kidney Diseases Obesity Obesity, Morbid Observational Studies as Topic Prospective Studies Weight Loss
Obesity, including morbid obesity, is a growing worldwide problem. The adverse effect of obesity on the kidneys is associated with the development of comorbid conditions, such as insulin resistance (IR), metabolic syndrome (MS), diabetes mellitus (DM), arterial hypertension (AH), which are the recognized risk factors of chronic kidney disease (ÑKD). Obesity also causes direct kidney damage with the development of non-immune focal segmental glomerulosclerosis. The leading pathophysiological mechanisms of kidney damage in obesity are intrarenal hemodynamic disorders with the formation of hyperfiltration and damaging effects of adipokines produced by adipose tissue. Bariatric surgery (BS) has taken a leading position in the treatment of morbid obesity, demonstrating its effectiveness not only in long-term weight loss, but also in the correction of IR, MS, DM, AH. Nephroprotective effect of significant and persistent weight loss is caused by the elimination of hyperfiltration and damaging