Journal of Pharmaceutical Sciences and Research
Vol.10, Issue6, P. 1457-1460
Аннотация:
The experimental study uses a modern approach to the pharmaceutical development of innovative forms of L-Dopa by incorporating nanosomal L-Dopa in biodegradable polymer PLGA nanoparticles and using the promising nasal route of administration alternative to the oral one in the treatment of Parkinson's disease. PLGA nanoparticles provide for the stability of L-Dopa and increase bioavailability as a result of its controlled and sustained release. Nano-L-Dopa based on PLGA nanoparticles contains the following components: L-Dopa, PLGA polymer, D-mannitol, polyvinyl alcohol. The work is devoted to studying of the physicochemical properties, the definition of quality attributes and methods of analysis of Nano-L-Dopa based on PLGA-nanoparticles for nasal treatment of Parkinson's disease. The content of L-Dopa and its impurities in the obtained experimental Nano-L-Dopa samples has been quantified. The identification identificationof PLGA nanoparticles has been established. The obtained results
Ключевые слова:
Drug quality attributes; Nano-L-DOPA; Nanoparticles; Nasal administration; Parkinson’s disease; Physicochemical properties; PLGA
levodopa; mannitol; nanoparticle; polyglactin; polyvinyl alcohol; Article; degradation; drug bioavailability; drug delivery system; drug determination; drug formulation; drug metabolism; drug quality; drug solubility; drug stability; flow rate; high performance liquid chromatography; infrared spectroscopy; laser diffraction; Parkinson disease; particle size; pH; physical chemistry; potentiometry; sedimentation; water content
Pavlov A. N. Aleksej Nikitich 1988-
Pyatigorskaya N. V. Natal`ya Valeryevna 1965-
Brkich G. E`. Galina E`duardovna 1967-
Kedik S. A.
Panov A. V.
Павлов А. Н. Алексей Никитич 1988-
Пятигорская Н. В. Наталья Валерьевна 1965-
Бркич Г. Э. Галина Эдуардовна 1967-
Кедик С. А.
Панов А. В.
The research of physicochemical properties and determination of Nano-L-DOPA quality attributes based on PLGA nanoparticles for the treatment of parkinson's disease
The research of physicochemical properties and determination of Nano-L-DOPA quality attributes based on PLGA nanoparticles for the treatment of...
Текст визуальный непосредственный
Journal of Pharmaceutical Sciences and Research
Vol.10, Issue6 P. 1457-1460
2018
Статья
Drug quality attributes Nano-L-DOPA Nanoparticles Nasal administration Parkinson’s disease Physicochemical properties PLGA
levodopa mannitol nanoparticle polyglactin polyvinyl alcohol Article degradation drug bioavailability drug delivery system drug determination drug formulation drug metabolism drug quality drug solubility drug stability flow rate high performance liquid chromatography infrared spectroscopy laser diffraction Parkinson disease particle size pH physical chemistry potentiometry sedimentation water content
The experimental study uses a modern approach to the pharmaceutical development of innovative forms of L-Dopa by incorporating nanosomal L-Dopa in biodegradable polymer PLGA nanoparticles and using the promising nasal route of administration alternative to the oral one in the treatment of Parkinson's disease. PLGA nanoparticles provide for the stability of L-Dopa and increase bioavailability as a result of its controlled and sustained release. Nano-L-Dopa based on PLGA nanoparticles contains the following components: L-Dopa, PLGA polymer, D-mannitol, polyvinyl alcohol. The work is devoted to studying of the physicochemical properties, the definition of quality attributes and methods of analysis of Nano-L-Dopa based on PLGA-nanoparticles for nasal treatment of Parkinson's disease. The content of L-Dopa and its impurities in the obtained experimental Nano-L-Dopa samples has been quantified. The identification identificationof PLGA nanoparticles has been established. The obtained results