Аннотация:
Aim. To evaluate clinical features and outcomes of renal involvement in patients with microscopic polyangiitis (MPA). Materials and methods: We enrolled 99 patients with MPA, diagnosed in accordance with the algorithm of the European Medicines Evaluation Agency (EMEA) and the Chapel Hill consensus conference definition (2012). Serum creatinine (sCr), estimated glomerular filtration rate (EGFR), hematuria and proteinuria were estimated. Frequency of rapidly progressive renal failure (a twofold increase in the sCr level in ≤3 months) was regarded as the clinical equivalent of rapidly progressive glomerulonephritis (RPGN). Results and discussion. Renal involvement was present in 92 (92.9[%]) patients. RPGN developed in 51 (55,4[%]) patients. The most common features of kidney involvement were hematuria and subnephrotic proteinuria. Arterial hypertension was revealed in 32 (34.7[%]) patients and was associated with RPGN (p<0.004). End-stage renal disease (ESRD) developed in 11 (11.9[%]) patients.
Ключевые слова:
ANCA-associated vasculitis; Microscopic polyangiitis; Rapidly progressive glomerulonephritis
neutrophil cytoplasmic antibody; chronic kidney failure; complication; glomerulonephritis; human; kidney; microscopic polyangiitis; pathology; prognosis; Antibodies, Antineutrophil Cytoplasmic; Glomerulonephritis; Humans; Kidney; Kidney Failure, Chronic; Microscopic Polyangiitis; Prognosis
Щеголева Е. М. Елена Маратовна 1990-
Буланов Н. М. Николай Михайлович 1988-
Новиков П. И. Павел Игоревич 1982-
Моисеев С. В. Сергей Валентинович 1960-
Shhegoleva E. M. Elena Maratovna 1990-
Bulanov N. M. Nikolay Mikhaylovich 1988-
Novikov P. I. Pavel Igorevich 1982-
Moiseev S. V. Sergej Valentinovich 1960-
Clinical features of kidney involvement in microscopic microscopic polyangiitis
Текст визуальный непосредственный
Терапевтический архив
Медицинское маркетинговое агентство "МедиаМедика"
Т. 90, Вып. 6 С. 55-58
2018
Статья
ANCA-associated vasculitis Microscopic polyangiitis Rapidly progressive glomerulonephritis
neutrophil cytoplasmic antibody chronic kidney failure complication glomerulonephritis human kidney microscopic polyangiitis pathology prognosis Antibodies, Antineutrophil Cytoplasmic Glomerulonephritis Humans Kidney Kidney Failure, Chronic Microscopic Polyangiitis Prognosis
Aim. To evaluate clinical features and outcomes of renal involvement in patients with microscopic polyangiitis (MPA). Materials and methods: We enrolled 99 patients with MPA, diagnosed in accordance with the algorithm of the European Medicines Evaluation Agency (EMEA) and the Chapel Hill consensus conference definition (2012). Serum creatinine (sCr), estimated glomerular filtration rate (EGFR), hematuria and proteinuria were estimated. Frequency of rapidly progressive renal failure (a twofold increase in the sCr level in ≤3 months) was regarded as the clinical equivalent of rapidly progressive glomerulonephritis (RPGN). Results and discussion. Renal involvement was present in 92 (92.9[%]) patients. RPGN developed in 51 (55,4[%]) patients. The most common features of kidney involvement were hematuria and subnephrotic proteinuria. Arterial hypertension was revealed in 32 (34.7[%]) patients and was associated with RPGN (p<0.004). End-stage renal disease (ESRD) developed in 11 (11.9[%]) patients.