Аннотация:
Obstetric atypical hemolytic uremic syndrome (aHUS) is one of the reasons for the development of acute kidney injury (AKI) and can determine the prognosis of both mother and child. Aim. Analysis of clinical manifestations, course and outcomes of obstetric aHUS. Materials and methods. 45 patients with aHUS development during pregnancy or immediately after childbirth were observed between 2011 and 2017, age from 16 to 42 years. Results and discussion. All patients had AKI (serum creatinine 521,5±388,0 μmol/l, oliguria or anuria that required initiation of hemodialysis). 93.3[%] pts had extrarenal manifestations of TMA with the development of multiple organ failure (MOF). The mean number of damage organs was 3,7±1,2. In all patients, the development of aHUS was preceded by obstetric complications, surgery, infection, etc. In the outcome: 53.4[%] women showed complete recovery of renal function, 11.1[%] developed CKD 4-5 stages, 35.5[%] had dialysis-dependent end-stage renal failure (ESDR). Matern
Ключевые слова:
Acute kidney injury; Atypical hemolytic uremic syndrome; Eculizumab; Pregnancy
creatinine; acute kidney failure; chronic kidney failure; complication; female; hemodialysis; hemolytic uremic syndrome; human; male; pregnancy; pregnancy complication; Acute Kidney Injury; Atypical Hemolytic Uremic Syndrome; Creatinine; Female; Humans; Kidney Failure, Chronic; Male; Pregnancy; Pregnancy Complications; Renal Dialysis
Козловская Н. Л. Наталья Львовна 1951-
Коротчаева Ю. В. Юлия Вячеславовна 1973-
Шифман Е. М.
Боброва Л. А. Лариса Александровна 1977-
Kozlovskaya N. L. Natal`ya L`vovna 1951-
Korotchaeva Yu. V. Yuliya Vyacheslavovna 1973-
Shifman E. M.
Bobrova L. A. Larisa Aleksandrovna 1977-
Atypical hemolytic-uremic syndrome as one of the causes of acute kidney injury in pregnant women
Текст визуальный непосредственный
Терапевтический архив
Медицинское маркетинговое агентство "МедиаМедика"
Т. 90, Вып. 6 С. 28-34
2018
Статья
Acute kidney injury Atypical hemolytic uremic syndrome Eculizumab Pregnancy
creatinine acute kidney failure chronic kidney failure complication female hemodialysis hemolytic uremic syndrome human male pregnancy pregnancy complication Acute Kidney Injury Atypical Hemolytic Uremic Syndrome Creatinine Female Humans Kidney Failure, Chronic Male Pregnancy Pregnancy Complications Renal Dialysis
Obstetric atypical hemolytic uremic syndrome (aHUS) is one of the reasons for the development of acute kidney injury (AKI) and can determine the prognosis of both mother and child. Aim. Analysis of clinical manifestations, course and outcomes of obstetric aHUS. Materials and methods. 45 patients with aHUS development during pregnancy or immediately after childbirth were observed between 2011 and 2017, age from 16 to 42 years. Results and discussion. All patients had AKI (serum creatinine 521,5±388,0 μmol/l, oliguria or anuria that required initiation of hemodialysis). 93.3[%] pts had extrarenal manifestations of TMA with the development of multiple organ failure (MOF). The mean number of damage organs was 3,7±1,2. In all patients, the development of aHUS was preceded by obstetric complications, surgery, infection, etc. In the outcome: 53.4[%] women showed complete recovery of renal function, 11.1[%] developed CKD 4-5 stages, 35.5[%] had dialysis-dependent end-stage renal failure (ESDR). Matern