Аннотация:
Hepatitis C virus (HCV) is a global population problem due to its high prevalence, usually late diagnosis, the difficulties of treatment. In the prognosis of patients with HCV not only hepatic, but increasingly frequent of extrahepatic HCV manifestations, such as mixed cryoglobulinemia (CG), are important. Mixed CG is currently considered as a B-cell benign lymphoproliferative disorders. The role of HCV virus in the pathogenesis of lymphoproliferative diseases is confirmed by a large number of epidemiological studies, as well as by the effectiveness of antiviral therapy in patients with non-Hodgkin's lymphoma (NHL). The purpose of the review was to provide an overview of recent literature data and the meta-analysis of epidemiological data explaining the role of HCV in the development of NHL. The review also discusses the treatment for HCV-associated NHL by antiviral therapy or other therapeutic options, such as chemotherapy. © 2018 Media Sphera Publishing Group. All rights reserved.
Ключевые слова:
Antiviral therapy; B-cell non-hodgkin's lymphoma; Chemotherapy; Chronic hepatitis C; Mixed cryoglobulinemia
adult; B cell lymphoma; B lymphocyte; child; complication; cryoglobulinemia; Hepacivirus; hepatitis C; human; nonhodgkin lymphoma; Adult; B-Lymphocytes; Child; Cryoglobulinemia; Hepacivirus; Hepatitis C; Humans; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin
Милованова С. Ю. Светлана Юрьевна 1975-
Лысенко Л. В. Лидия Владимировна 1937-
Милованова Л. Ю. Людмила Юрьевна 1973-
Мрыхин Н. Н. Николай Николаевич 1973-
Русских А. В.
Мучин Н. А.
Milovanova S. Yu. Svetlana Yuryevna 1975-
Ly'senko L. V. Lidiya Vladimirovna 1937-
Milovanova L. Yu. Lyudmila Yuryevna 1973-
Mry'khin N. N. Nikolay Nikolaevich 1973-
Russkih A. V.
Muchin N. A.
HCV-associated mixed cryoglobulinemia and b-cell non-Hodgkin's lymphoma - pathogenetically related problems
Текст визуальный непосредственный
Терапевтический архив
Медицинское маркетинговое агентство "МедиаМедика"
Т. 90, Вып. 6 С. 112-120
2018
Статья
Antiviral therapy B-cell non-hodgkin's lymphoma Chemotherapy Chronic hepatitis C Mixed cryoglobulinemia
adult B cell lymphoma B lymphocyte child complication cryoglobulinemia Hepacivirus hepatitis C human nonhodgkin lymphoma Adult B-Lymphocytes Child Cryoglobulinemia Hepacivirus Hepatitis C Humans Lymphoma, B-Cell Lymphoma, Non-Hodgkin
Hepatitis C virus (HCV) is a global population problem due to its high prevalence, usually late diagnosis, the difficulties of treatment. In the prognosis of patients with HCV not only hepatic, but increasingly frequent of extrahepatic HCV manifestations, such as mixed cryoglobulinemia (CG), are important. Mixed CG is currently considered as a B-cell benign lymphoproliferative disorders. The role of HCV virus in the pathogenesis of lymphoproliferative diseases is confirmed by a large number of epidemiological studies, as well as by the effectiveness of antiviral therapy in patients with non-Hodgkin's lymphoma (NHL). The purpose of the review was to provide an overview of recent literature data and the meta-analysis of epidemiological data explaining the role of HCV in the development of NHL. The review also discusses the treatment for HCV-associated NHL by antiviral therapy or other therapeutic options, such as chemotherapy. © 2018 Media Sphera Publishing Group. All rights reserved.