Аннотация:
Objective. To compare the frequency, clinical features and outcomes of renal involvement in ANCA-associated vasculitides (AAV) in patients with antibodies against proteinase-3 (pr3-ANCA) and myeloperoxidase (MPO-ANCA). Materials and methods. In our retrospective study we enrolled 264 patients, 94 males and 170 females, median age 53 [36; 62] years. Among them 157 were pr3-ANCA positive and 107 were MPO-ANCA positive. AAV was diagnosed according to ACR criteria and Chapel Hill consensus conference definition (2012). Median follow up was 44 [18; 93] months. We assessed baseline BVAS and VDI by the end of the follow up. Serum creatinine (sCr), estimated glomerular filtration rate (EGFR), hematuria and daily proteinuria were estimated. Diagnosis and stage of chronic kidney disease (CKD) and acute kidney injury (AKI) were established according to KDIGO guidelines (2012) and Scientific Society of Russian Nephrologists (2016). Results. Renal involvement was present in 181 (68.6[%]) patients, an
Ключевые слова:
ANCA-associated vasculitis; Glomerulonephritis; Myeloperoxidase; Proteinase-3
myeloblastin; neutrophil cytoplasmic antibody; ANCA associated vasculitis; complication; female; human; kidney disease; male; middle aged; retrospective study; Russian Federation; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Antibodies, Antineutrophil Cytoplasmic; Female; Humans; Kidney Diseases; Male; Middle Aged; Myeloblastin; Retrospective Studies; Russia
Буланов Н. М. Николай Михайлович 1988-
Макаров Е. А.
Щеголева Е. М. Елена Маратовна 1990-
Зыкова А. С. Анастасия Сергеевна 1991-
Виноградова Е. С. Екатерина Сергеевна 1990-
Новиков П. И. Павел Игоревич 1982-
Лысенко Л. В. Лидия Владимировна 1937-
Моисеев С. В. Сергей Валентинович 1960-
Bulanov N. M. Nikolay Mikhaylovich 1988-
Makarov E. A.
Shhegoleva E. M. Elena Maratovna 1990-
Zy'kova A. S. Anastasiya Sergeevna 1991-
Vinogradova E. S. Ekaterina Sergeevna 1990-
Novikov P. I. Pavel Igorevich 1982-
Ly'senko L. V. Lidiya Vladimirovna 1937-
Moiseev S. V. Sergej Valentinovich 1960-
Relationship between serologic profile (ANCA type) and clinical features of renal involvement in ANCA-associated vasculitides
Текст визуальный непосредственный
Терапевтический архив
Медицинское маркетинговое агентство "МедиаМедика"
Т. 90, Вып. 6 С. 15-21
2018
Статья
ANCA-associated vasculitis Glomerulonephritis Myeloperoxidase Proteinase-3
myeloblastin neutrophil cytoplasmic antibody ANCA associated vasculitis complication female human kidney disease male middle aged retrospective study Russian Federation Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Antibodies, Antineutrophil Cytoplasmic Female Humans Kidney Diseases Male Middle Aged Myeloblastin Retrospective Studies Russia
Objective. To compare the frequency, clinical features and outcomes of renal involvement in ANCA-associated vasculitides (AAV) in patients with antibodies against proteinase-3 (pr3-ANCA) and myeloperoxidase (MPO-ANCA). Materials and methods. In our retrospective study we enrolled 264 patients, 94 males and 170 females, median age 53 [36; 62] years. Among them 157 were pr3-ANCA positive and 107 were MPO-ANCA positive. AAV was diagnosed according to ACR criteria and Chapel Hill consensus conference definition (2012). Median follow up was 44 [18; 93] months. We assessed baseline BVAS and VDI by the end of the follow up. Serum creatinine (sCr), estimated glomerular filtration rate (EGFR), hematuria and daily proteinuria were estimated. Diagnosis and stage of chronic kidney disease (CKD) and acute kidney injury (AKI) were established according to KDIGO guidelines (2012) and Scientific Society of Russian Nephrologists (2016). Results. Renal involvement was present in 181 (68.6[%]) patients, an