Turning Off the Tap: Using the FAST Approach to Stop the Spread of Drug-Resistant Tuberculosis in the Russian Federation
Miller A. C., Livchits V., Ahmad K. F., Atwood S., Kornienko S., Kononenko Y., Vasilyeva I. A., Keshavjee S.
Journal of Infectious Diseases
Vol.218, Issue4, P. 654-658
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.1093/infdis/jiy190
Аннотация:
Background We report the association of the FAST strategy (find cases actively, separate safely, and treat effectively) with reduction of hospital-based acquisition of multidrug-resistant tuberculosis in the Russian Federation. Methods We used preintervention and postintervention cohorts in 2 Russian hospitals to determine whether the FAST strategy was associated with a reduced odds of converting MDR tuberculosis within 12 months among patients with tuberculosis susceptible to isoniazid and rifampin at baseline. Results Sixty-three of 709 patients (8.9[%]) with isoniazid and rifampin-susceptible tuberculosis acquired MDR tuberculosis; 55 (12.2[%]) were in the early cohort, and 8 (3.1[%]) were in the FAST cohort. The FAST strategy was associated with a reduced odds (adjusted odds ratio, 0.16; 95[%] confidence interval,.07-.39) and 9.2[%] absolute reduction in the risk of MDR tuberculosis acquisition. Conclusion Use of the FAST strategy in 2 Russian hospitals was associated with significantly less
Ключевые слова:
hospital infection control; Multidrug-resistant tuberculosis; nosocomial transmission; Russian Federation; tuberculosis
ethambutol; isoniazid; pyrazinamide; rifampicin; streptomycin; adult; antibiotic sensitivity; Article; bacterium culture; case finding; cohort analysis; controlled study; directly observed therapy; drug efficacy; female; human; major clinical study; male; multidrug resistant tuberculosis; Mycobacterium tuberculosis; patient isolation; priority journal; risk reduction; Russian Federation; sputum smear; thorax radiography; treatment duration; adolescent; aged; communicable disease control; disease transmission; health services research; hospital; middle aged; multidrug resistant tuberculosis; organization and management; prevention and control; procedures; Russian Federation; very elderly; young adult; Adolescent; Adult; Aged; Aged, 80 and over; Communicable Disease Control; Disease Transmission, Infectious; Female; Health Services Research; Hospitals; Humans; Male; Middle Aged; Russia; Tuberculosis, Multidrug-Resistant; Young Adult
Язык текста: Английский
ISSN: 1537-6613
Miller A. C.
Livchits V.
Ahmad K. F. Khan F.
Atwood S.
Kornienko S.
Kononenko Y.
Vasilyeva I. A. Irina Anatolyevna 1966-
Keshavjee S.
Миллер А. C.
Ливчиц В.
Ахмад К. Ф. Хан Ф.
Атwоод С.
Корниенко С.
Кононенко Y.
Васильева И. А. Ирина Анатольевна 1966-
Кешавйее С.
Turning Off the Tap: Using the FAST Approach to Stop the Spread of Drug-Resistant Tuberculosis in the Russian Federation
Текст визуальный непосредственный
Journal of Infectious Diseases
Редакция журнала ЭКО
Vol.218, Issue4 P. 654-658
2018
Статья
hospital infection control Multidrug-resistant tuberculosis nosocomial transmission Russian Federation tuberculosis
ethambutol isoniazid pyrazinamide rifampicin streptomycin adult antibiotic sensitivity Article bacterium culture case finding cohort analysis controlled study directly observed therapy drug efficacy female human major clinical study male multidrug resistant tuberculosis Mycobacterium tuberculosis patient isolation priority journal risk reduction Russian Federation sputum smear thorax radiography treatment duration adolescent aged communicable disease control disease transmission health services research hospital middle aged multidrug resistant tuberculosis organization and management prevention and control procedures Russian Federation very elderly young adult Adolescent Adult Aged Aged, 80 and over Communicable Disease Control Disease Transmission, Infectious Female Health Services Research Hospitals Humans Male Middle Aged Russia Tuberculosis, Multidrug-Resistant Young Adult
Background We report the association of the FAST strategy (find cases actively, separate safely, and treat effectively) with reduction of hospital-based acquisition of multidrug-resistant tuberculosis in the Russian Federation. Methods We used preintervention and postintervention cohorts in 2 Russian hospitals to determine whether the FAST strategy was associated with a reduced odds of converting MDR tuberculosis within 12 months among patients with tuberculosis susceptible to isoniazid and rifampin at baseline. Results Sixty-three of 709 patients (8.9[%]) with isoniazid and rifampin-susceptible tuberculosis acquired MDR tuberculosis; 55 (12.2[%]) were in the early cohort, and 8 (3.1[%]) were in the FAST cohort. The FAST strategy was associated with a reduced odds (adjusted odds ratio, 0.16; 95[%] confidence interval,.07-.39) and 9.2[%] absolute reduction in the risk of MDR tuberculosis acquisition. Conclusion Use of the FAST strategy in 2 Russian hospitals was associated with significantly less