Atypical Goodpasture's disease: A clinical case report and literature review
Буланова М. Л., Потапов Д. В., Буланов Н. М., Лысенко Л. В.
Терапевтический архив
Т. 90, Вып. 6, С. 130-136
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.26442/terarkh2018906130-136
Аннотация:
Goodpasture's disease (anti-GBM disease) is a rare small vessels vasculitis characterized by the presence of autoantibodies directed against the glomerular basement membrane (GBM) and alveolar basement membrane. Common feature of anti-GBM disease is a combination of rapidly progressive glomerulonephritis and alveolar hemorrhage (pulmonary-renal syndrome). We present a case of atypical disease course in a young male patient who developed alveolar hemorrhage without renal failure. The only symptom of renal involvement was isolated hematuria. Plasmapheresis combined with immunosuppression (cyclophosphamide and corticosteroids) was effective. We present a review of state-of-art data on the pathogenesis and disease course of anti-GBM disease. © 2018 Media Sphera Publishing Group. All rights reserved.
Ключевые слова:
Anti-GBM disease; Anti-glomerular basement membrane antibodies; Goodpasture's disease; Plasmapheresis; Pulmonary hemorrhage
autoantibody; cyclophosphamide; bleeding; case report; complication; glomerulonephritis; hematuria; human; male; Anti-Glomerular Basement Membrane Disease; Autoantibodies; Cyclophosphamide; Glomerulonephritis; Hematuria; Hemorrhage; Humans; Male
Язык текста: Русский
ISSN: 2309-5342
Буланова М. Л.
Потапов Д. В.
Буланов Н. М. Николай Михайлович 1988-
Лысенко Л. В. Лидия Владимировна 1937-
Bulanova M. L.
Potapov D. V.
Bulanov N. M. Nikolay Mikhaylovich 1988-
Ly'senko L. V. Lidiya Vladimirovna 1937-
Atypical Goodpasture's disease: A clinical case report and literature review
Текст визуальный непосредственный
Терапевтический архив
Медицинское маркетинговое агентство "МедиаМедика"
Т. 90, Вып. 6 С. 130-136
2018
Статья
Anti-GBM disease Anti-glomerular basement membrane antibodies Goodpasture's disease Plasmapheresis Pulmonary hemorrhage
autoantibody cyclophosphamide bleeding case report complication glomerulonephritis hematuria human male Anti-Glomerular Basement Membrane Disease Autoantibodies Cyclophosphamide Glomerulonephritis Hematuria Hemorrhage Humans Male
Goodpasture's disease (anti-GBM disease) is a rare small vessels vasculitis characterized by the presence of autoantibodies directed against the glomerular basement membrane (GBM) and alveolar basement membrane. Common feature of anti-GBM disease is a combination of rapidly progressive glomerulonephritis and alveolar hemorrhage (pulmonary-renal syndrome). We present a case of atypical disease course in a young male patient who developed alveolar hemorrhage without renal failure. The only symptom of renal involvement was isolated hematuria. Plasmapheresis combined with immunosuppression (cyclophosphamide and corticosteroids) was effective. We present a review of state-of-art data on the pathogenesis and disease course of anti-GBM disease. © 2018 Media Sphera Publishing Group. All rights reserved.