Аннотация:
In the review, the mechanisms of podocytes damage underlying the development of proteinuria and progression of glomerulosclerosis in chronic glomerulonephritis are discussed in detail. The results of experimental and clinical studies are presented. Under the different immune and non-immune factors the podocytes form a stereotyped response to damage consisting in the reorganization of the actin cytoskeleton, foot process effacement, the detachment of podocytes from the glomerular basement membrane, and the appearance of specific podocyte proteins and whole cells (podocyturia) in the urine. Massive podocyturia in a limited proliferative capacity of podocytes leads to reduce their total count in the glomerulus (podocytopenia) and the development of glomerulosclerosis. The authors describe the line of markers of the podocyte injury and invasive and non-invasive methods of their assessment. In addition, the relationship of podocyturia level with proteinuria and renal dysfunction are discuss
Ключевые слова:
Chronic glomerulonephritis; Nephrinuria; Podocyte dysfunction; Podocytopenia; Podocyturia
disease exacerbation; glomerulonephritis; glomerulus; human; pathophysiology; podocyte; proteinuria; Disease Progression; Glomerulonephritis; Humans; Kidney Glomerulus; Podocytes; Proteinuria
Чеботарева Н. В. Наталья Викторовна 1976-
Бобкова И. Н. Ирина Николаевна 1967-
Лысенко Л. В. Лидия Владимировна 1937-
Chebotareva N. V. Natal`ya Viktorovna 1976-
Bobkova I. N. Irina Nikolaevna 1967-
Ly'senko L. V. Lidiya Vladimirovna 1937-
The role of podocytes dysfunction in chronic glomerulonephritis progression
Текст визуальный непосредственный
Терапевтический архив
Медицинское маркетинговое агентство "МедиаМедика"
Т. 90, Вып. 6 С. 92-97
2018
Статья
Chronic glomerulonephritis Nephrinuria Podocyte dysfunction Podocytopenia Podocyturia
disease exacerbation glomerulonephritis glomerulus human pathophysiology podocyte proteinuria Disease Progression Glomerulonephritis Humans Kidney Glomerulus Podocytes Proteinuria
In the review, the mechanisms of podocytes damage underlying the development of proteinuria and progression of glomerulosclerosis in chronic glomerulonephritis are discussed in detail. The results of experimental and clinical studies are presented. Under the different immune and non-immune factors the podocytes form a stereotyped response to damage consisting in the reorganization of the actin cytoskeleton, foot process effacement, the detachment of podocytes from the glomerular basement membrane, and the appearance of specific podocyte proteins and whole cells (podocyturia) in the urine. Massive podocyturia in a limited proliferative capacity of podocytes leads to reduce their total count in the glomerulus (podocytopenia) and the development of glomerulosclerosis. The authors describe the line of markers of the podocyte injury and invasive and non-invasive methods of their assessment. In addition, the relationship of podocyturia level with proteinuria and renal dysfunction are discuss