Diagnosis of IgG4 - related ophthalmic disease in a group of patients with various lesions of the eye and orbits
Васильев В. И., Сафонова Т. Н., Соcол Е. В., Пробатова Н. А., Кокосадзе Н. В., Павловскайа А. И., Ковригина А. М., Раденска-Лоповок С. Г., Городецкy В. Р., Родионова Е. Б., Палшина С. Г., Александрова Е. Н., Шорникова Н. С., Гаидук И. В.
Терапевтический архив
Т. 90, Вып. 5, С. 61-71
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.26442/terarkh201890561-71
Аннотация:
Purpose of the study. To provide demographic, clinical, laboratory, ultrasound, radiological, morphological/ immunomorphological phenotype of IgG4-related ophthalmic diseases, which allowsmaking a differential diagnosis with granulomatous, autoimmune, inflammatory, endocrine and hematologic diseases affecting the eye and orbits. Materials and methods. From 2004 to 2016 108 (78.2[%]) of the 138 patients were diagnosed with non-tumoral lesions of eye and orbits. In 48 patients (35[%]) at admission and 5 patients in the follow were diagnosed IgG4-related ophthalmic disease. In the analysis of 82 (f-44, m- 38) patients with IgG4-related disease, localization of lesions in orbit observed in 53 (f-36, m-17) and it was the most frequent involvement in patients with IgG4-related disease (64.5[%]). Only 7 patients had isolated IgG4-related ophthalmic disease, whereas 46 patients (87[%]) had involvement of 2-7 locations, as a manifestation of IgG4-related systemic disease.During the examination, the ave
Ключевые слова:
Dacryoadenitis; Defeat of the orbital and trigeminal nerve branches associated with IgG4 (IgG4-related ophthalmic disease); Immunoglobulin G of 4-th subclass (IgG4); Infiltration of extraocular muscles and eyelids; Retrobulbar infiltration
immunoglobulin G; autoimmune disease; eye disease; female; human; middle aged; orbit; plasma cell; Autoimmune Diseases; Eye Diseases; Female; Humans; Immunoglobulin G; Immunoglobulin G4-Related Disease; Middle Aged; Orbit; Plasma Cells
Язык текста: Русский
ISSN: 2309-5342
Васильев В. И.
Сафонова Т. Н.
Соcол Е. В.
Пробатова Н. А.
Кокосадзе Н. В.
Павловскайа А. И.
Ковригина А. М.
Раденска-Лоповок С. Г. Стефка Господинова 1951-
Городецкy В. Р.
Родионова Е. Б.
Палшина С. Г.
Александрова Е. Н.
Шорникова Н. С.
Гаидук И. В.
Vasilyev V. I.
Safonova T. N.
Socol E. V.
Probatova N. A.
Kokosadze N. V.
Pavlovskaya A. I.
Kovrigina A. M.
Radenska-Lopovok S. G. Stefka Gospodinova 1951-
Gorodetsky V. R.
Rodionova E. B.
Palshina S. G.
Aleksandrova E. N.
Shornikova N. S.
Gaiduk I. V.
Diagnosis of IgG4 - related ophthalmic disease in a group of patients with various lesions of the eye and orbits
Текст визуальный непосредственный
Терапевтический архив
Медицинское маркетинговое агентство "МедиаМедика"
Т. 90, Вып. 5 С. 61-71
2018
Статья
Dacryoadenitis Defeat of the orbital and trigeminal nerve branches associated with IgG4 (IgG4-related ophthalmic disease) Immunoglobulin G of 4-th subclass (IgG4) Infiltration of extraocular muscles and eyelids Retrobulbar infiltration
immunoglobulin G autoimmune disease eye disease female human middle aged orbit plasma cell Autoimmune Diseases Eye Diseases Female Humans Immunoglobulin G Immunoglobulin G4-Related Disease Middle Aged Orbit Plasma Cells
Purpose of the study. To provide demographic, clinical, laboratory, ultrasound, radiological, morphological/ immunomorphological phenotype of IgG4-related ophthalmic diseases, which allowsmaking a differential diagnosis with granulomatous, autoimmune, inflammatory, endocrine and hematologic diseases affecting the eye and orbits. Materials and methods. From 2004 to 2016 108 (78.2[%]) of the 138 patients were diagnosed with non-tumoral lesions of eye and orbits. In 48 patients (35[%]) at admission and 5 patients in the follow were diagnosed IgG4-related ophthalmic disease. In the analysis of 82 (f-44, m- 38) patients with IgG4-related disease, localization of lesions in orbit observed in 53 (f-36, m-17) and it was the most frequent involvement in patients with IgG4-related disease (64.5[%]). Only 7 patients had isolated IgG4-related ophthalmic disease, whereas 46 patients (87[%]) had involvement of 2-7 locations, as a manifestation of IgG4-related systemic disease.During the examination, the ave