Extracellular matrix in the central nervous system
Dominova I. N., Patrushev M. V., Silina E. V., Shusharina N. N.
Journal of Pharmaceutical Sciences and Research
Vol.10, Issue4, P. 768-776
Опубликовано: 2018
Тип ресурса: Статья
Аннотация:
Central nervous system controls all the processes of the body through carefully honed neural network. This continuous activity is carried out with the help of neurons, glial cells and extracellular matrix. This review presents the main components of the extracellular matrix and characteristics of their participation in normal and pathological processes occurring in the central nervous system, as well as perineuronal networks that represent a unique variety of extracellular matrix surrounding neuronal cell bodies, their axons, dendrites, and glial cells. As a rule, perineuronal networks are localized around soma and dendrites and delimit synapses on neuronal surfaces. We have identified the prevailing mechanisms of interaction of brain cells with extracellular matrix, which provide modulation of neuronal plasticity and are crucial for the development and functioning of the central nervous system. © 2018, Pharmainfo Publications. All rights reserved.
Ключевые слова:
Astrocytes; Extracellular matrix; Glia; Lamins; Neurons; Proteoglycans; Reelin; Tenascins
aggrecan; chondroitin sulfate; hyaluronic acid; laminin; neurocan; proteoglycan; reelin; tenascin; thrombospondin; versican; Article; axon; central nervous system; dendrite; extracellular matrix; gene mutation; glia cell; human; nerve cell network; nerve cell plasticity; neurite outgrowth; nonhuman; protein expression; spinal cord injury; synaptic transmission; synaptogenesis
Язык текста: Английский
ISSN: 0975-1459
Dominova I. N.
Patrushev M. V.
Silina E. V. Ekaterina Vladimirovna 1980-
Shusharina N. N.
Доминова И. Н.
Патрушев М. В.
Силина Е. В. Екатерина Владимировна 1980-
Шушарина Н. Н.
Extracellular matrix in the central nervous system
Текст визуальный непосредственный
Journal of Pharmaceutical Sciences and Research
Vol.10, Issue4 P. 768-776
2018
Статья
Astrocytes Extracellular matrix Glia Lamins Neurons Proteoglycans Reelin Tenascins
aggrecan chondroitin sulfate hyaluronic acid laminin neurocan proteoglycan reelin tenascin thrombospondin versican Article axon central nervous system dendrite extracellular matrix gene mutation glia cell human nerve cell network nerve cell plasticity neurite outgrowth nonhuman protein expression spinal cord injury synaptic transmission synaptogenesis
Central nervous system controls all the processes of the body through carefully honed neural network. This continuous activity is carried out with the help of neurons, glial cells and extracellular matrix. This review presents the main components of the extracellular matrix and characteristics of their participation in normal and pathological processes occurring in the central nervous system, as well as perineuronal networks that represent a unique variety of extracellular matrix surrounding neuronal cell bodies, their axons, dendrites, and glial cells. As a rule, perineuronal networks are localized around soma and dendrites and delimit synapses on neuronal surfaces. We have identified the prevailing mechanisms of interaction of brain cells with extracellular matrix, which provide modulation of neuronal plasticity and are crucial for the development and functioning of the central nervous system. © 2018, Pharmainfo Publications. All rights reserved.