Аннотация:
Tick-borne encephalitis (TBE), caused by the TBE virus (TBEV), is a serious public health threat in northern Eurasia. Three subtypes of TBEV are distinguished. Inactivated vaccines are available for TBE prophylaxis, and their efficacy to prevent the disease has been demonstrated by years of implication. Nevertheless, rare TBE cases among the vaccinated have been registered. The present study aimed to evaluate the protective efficacy of 4 TBEV vaccines against naturally circulating TBEV variants. For the first time, the protection was evaluated against an extended number of phylogenetically distinct TBEV strains isolated in different years in different territories. The protective effect did not strongly depend on the infectious dose of the challenge virus or the scheme of vaccination. All vaccines induced neutralizing antibodies in protective titers against the TBEV strains used, although the vaccines varied in the spectra of induced antibodies and protective efficacy. The protective ef
Ключевые слова:
Antibody; Antigen determinants; E protein; Immune response; TBE vaccine; TBEV
amino acid; epitope; tick borne encephalitis vaccine; animal cell; animal experiment; Article; Europe; mouse; nonhuman; phylogeny; prophylaxis; protein structure; sequence alignment; tick borne encephalitis; Tick borne encephalitis virus; vaccine immunogenicity
Chernokhaeva L. L.
Rogova Y. V.
Kozlovskaya L. I. Lyubov` Igorevna 1984-
Romanova L. I. Lidiya Ivanovna 1942-
Osolodkin D. I. Dmitrij Ivanovich 1985-
Vorovich M. F. Mikhail Fridrikhovich 1961-
Karganova G. G. Galina Grigoryevna 1956-
Чернохаева Л. Л.
Рогова Y. В.
Козловская Л. И. Любовь Игоревна 1984-
Романова Л. И. Лидия Ивановна 1942-
Осолодкин Д. И. Дмитрий Иванович 1985-
Ворович М. Ф. Михаил Фридрихович 1961-
Карганова Г. Г. Галина Григорьевна 1956-
Experimental evaluation of the protective efficacy of tick-borne encephalitis (TBE) vaccines based on European and Far-Eastern TBEV strains in mice and in vitro
Experimental evaluation of the protective efficacy of tick-borne encephalitis (TBE) vaccines based on European and Far-Eastern TBEV strains in mice...
Текст визуальный непосредственный
Frontiers in Microbiology
Vol.9, IssueJUL Num.1487
2018
Статья
Antibody Antigen determinants E protein Immune response TBE vaccine TBEV
amino acid epitope tick borne encephalitis vaccine animal cell animal experiment Article Europe mouse nonhuman phylogeny prophylaxis protein structure sequence alignment tick borne encephalitis Tick borne encephalitis virus vaccine immunogenicity
Tick-borne encephalitis (TBE), caused by the TBE virus (TBEV), is a serious public health threat in northern Eurasia. Three subtypes of TBEV are distinguished. Inactivated vaccines are available for TBE prophylaxis, and their efficacy to prevent the disease has been demonstrated by years of implication. Nevertheless, rare TBE cases among the vaccinated have been registered. The present study aimed to evaluate the protective efficacy of 4 TBEV vaccines against naturally circulating TBEV variants. For the first time, the protection was evaluated against an extended number of phylogenetically distinct TBEV strains isolated in different years in different territories. The protective effect did not strongly depend on the infectious dose of the challenge virus or the scheme of vaccination. All vaccines induced neutralizing antibodies in protective titers against the TBEV strains used, although the vaccines varied in the spectra of induced antibodies and protective efficacy. The protective ef