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Effects of laser radiation on mitochondria and mitochondrial proteins subjected to nitric oxide

Osipov A. N., Machneva T. V., Buravlev E. A., Vladimirov Yu. A.
Frontiers in Medicine
Vol.5, IssueAPR, Num.112
Опубликовано: 2018
Тип ресурса: Обзор

DOI:10.3389/fmed.2018.00112/full

Аннотация:
The biological roles of heme and nonheme nitrosyl complexes in physiological and pathophysiological conditions as metabolic key players are considered in this study. Two main physiological functions of protein nitrosyl complexes are discussed-(1) a depot and potential source of free nitric oxide (NO) and (2) a controller of crucial metabolic processes. The first function is realized through the photolysis of nitrosyl complexes (of hemoglobin, cytochrome c, or mitochondrial iron-sulfur proteins). This reaction produces free NO and subsequent events are due to the NO physiological functions. The second function is implemented by the possibility of NO to bind heme and nonheme proteins and produce corresponding nitrosyl complexes. Enzyme nitrosyl complex formation usually results in the inhibition (or enhancement in the case of guanylate cyclase) of its enzymatic activity. Photolysis of protein nitrosyl complexes, in this case, will restore the original enzymatic activity. Thus, cytochrome
Ключевые слова:
Hemoproteins; Laser therapy; Liver; Mitochondria; Mitochondrial proteins; Nitric oxide
Язык текста: Английский
ISSN: 2296-858X
Osipov A. N.
Machneva T. V.
Buravlev E. A. Evgenij Aleksandrovich 1986-
Vladimirov Yu. A. Yurij Andreevich 1932-
Осипов А. Н.
Мачнева Т. В.
Буравлев Е. А. Евгений Александрович 1986-
Владимиров Ю. А. Юрий Андреевич 1932-
Effects of laser radiation on mitochondria and mitochondrial proteins subjected to nitric oxide
Текст визуальный непосредственный
Frontiers in Medicine
Vol.5, IssueAPR Num.112
2018
Обзор
Hemoproteins Laser therapy Liver Mitochondria Mitochondrial proteins Nitric oxide
The biological roles of heme and nonheme nitrosyl complexes in physiological and pathophysiological conditions as metabolic key players are considered in this study. Two main physiological functions of protein nitrosyl complexes are discussed-(1) a depot and potential source of free nitric oxide (NO) and (2) a controller of crucial metabolic processes. The first function is realized through the photolysis of nitrosyl complexes (of hemoglobin, cytochrome c, or mitochondrial iron-sulfur proteins). This reaction produces free NO and subsequent events are due to the NO physiological functions. The second function is implemented by the possibility of NO to bind heme and nonheme proteins and produce corresponding nitrosyl complexes. Enzyme nitrosyl complex formation usually results in the inhibition (or enhancement in the case of guanylate cyclase) of its enzymatic activity. Photolysis of protein nitrosyl complexes, in this case, will restore the original enzymatic activity. Thus, cytochrome