Аннотация:
Diffusion tensor magnetic resonance imaging (DT-MRI) is the only noninvasive technique that makes it possible to study white matter microstructure in vivo and to quantify the images obtained. Objective: to study white matter in middle-aged treatment-naïve patients with uncomplicated grade 1-2 essential hypertension (EH), by using DT-MRI. Patients and methods. The investigation enrolled 82 people aged 40-59 years (41 patients with EH and 41 healthy individuals (a control group)). Twenty-four blood pressure monitoring and brain MRI were performed in different modes (T1 MPRAGE, T2 TSE, T2 FLAIR, and DTI). Results. White matter hyperintensities (WMHs) were found in 7.3[%] of the healthy individuals and in 53.7[%] of the hypertensive patients (p=0.0002). The latter had significantly lower fractional anisotropy (FA) values in the white matter of the left inferior frontal gyrus than the healthy individuals (0.39±0.06 and 0.45±0.09, respectively; p< 0.001). FA was lower in the hypertensive patient
Парфенов В. А. Владимир Анатольевич 1957-
Остроумова Т. М. Татьяна Максимовна 1991-
Остроумова О. Д. Ольга Дмитриевна 1968-
Перепелов В. А. Всеволод Андреевич 1984-
Перепелова Е. М. Елена Михайловна 1954-
Parfenov V. A. Vladimir Anatolyevich 1957-
Ostroumova T. M. Tat`yana Maksimovna 1991-
Ostroumova O. D. Ol`ga Dmitrievna 1968-
Perepelov V. A. Vsevolod Andreevich 1984-
Perepelova E. M. Elena Mikhaylovna 1954-
Diffusion tensor magnetic resonance imaging in the diagnosis of white matter lesion in middle-aged patients with uncomplicated essential hypertension
Текст визуальный непосредственный
Неврология, нейропсихиатрия, психосоматика
ИМА-Пресс
Т. 10, Вып. 2 С. 20-26
2018
Статья
Brain Diffusion tensor magnetic resonance imaging Fractional anisotropy Hypertension Magnetic resonance imaging Middle age Target organ damage White matter lesion
Diffusion tensor magnetic resonance imaging (DT-MRI) is the only noninvasive technique that makes it possible to study white matter microstructure in vivo and to quantify the images obtained. Objective: to study white matter in middle-aged treatment-naïve patients with uncomplicated grade 1-2 essential hypertension (EH), by using DT-MRI. Patients and methods. The investigation enrolled 82 people aged 40-59 years (41 patients with EH and 41 healthy individuals (a control group)). Twenty-four blood pressure monitoring and brain MRI were performed in different modes (T1 MPRAGE, T2 TSE, T2 FLAIR, and DTI). Results. White matter hyperintensities (WMHs) were found in 7.3[%] of the healthy individuals and in 53.7[%] of the hypertensive patients (p=0.0002). The latter had significantly lower fractional anisotropy (FA) values in the white matter of the left inferior frontal gyrus than the healthy individuals (0.39±0.06 and 0.45±0.09, respectively; p< 0.001). FA was lower in the hypertensive patient