Аннотация:
Background: This study discusses the crucial factors responsible for the progression of atherosclerotic cardiovascular disease (CVD). The interaction between the gut microbiota, heart and vessels in CVD pathogenesis is extremely complex and includes components such as direct bacterial translocation from the gut to vessels and metabolitemediated damage. To a greater extent, CVD seems to be entangled with a subtle immune system-to-microbiota interface. From among the most significant advances in recent years in this area, it is necessary to highlight the discovery of the pro-atherogenic effect of trimethylamine-N-oxide (TMAO) and changes in the activity of effector T-cells in the settings of dysbiosis. Currently, we are witnessing an explosive growth in interest in using the microbiota and interlinked cascades as a target for therapeutic interventions, including direct microbiome targeting, the attenuation of toxic metabolite-induced damage, the modulation of intestinal immunity, and dow
Ключевые слова:
Atherosclerosis; CVD; Dysbiosis; Gut microbiome; Heart failure; Trimethylamine-N-oxide
biological marker; dimethylaniline monooxygenase; G protein coupled receptor; lipopolysaccharide; probiotic agent; RNA 16S; toll like receptor; trimethylamine; trimethylamine oxide; atherosclerosis; bacterial translocation; cardiovascular disease; chronic kidney failure; coronary artery disease; dysbiosis; gene sequence; heart failure; heart failure with preserved ejection fraction; heart infarction; human; hypertension; immunity; intestine flora; metabolic syndrome X; microflora; nonhuman; obesity; personalized medicine; physical activity; Review
Ashikhmin Ya. I. Yaroslav Igorevich 1984-
Sy'rkin A. L. Abram L`vovich 1930-
Zamyatnin A. A. Andrej Aleksandrovich 1976-
Zhang Y.
Kopy'lov F. Yu. Filipp Yuryevich 1976-
Ашихмин Я. И. Ярослав Игоревич 1984-
Сыркин А. Л. Абрам Львович 1930-
Замятнин А. А. Андрей Александрович 1976-
Жанг Y.
Копылов Ф. Ю. Филипп Юрьевич 1976-
The gut microbiota in cardiovascular diseases: From biomarkers and potential targets to personalized interventions
Текст визуальный непосредственный
Current Pharmacogenomics and Personalized Medicine
Vol.16, Issue1 P. 75-85
2018
Обзор
Atherosclerosis CVD Dysbiosis Gut microbiome Heart failure Trimethylamine-N-oxide
biological marker dimethylaniline monooxygenase G protein coupled receptor lipopolysaccharide probiotic agent RNA 16S toll like receptor trimethylamine trimethylamine oxide atherosclerosis bacterial translocation cardiovascular disease chronic kidney failure coronary artery disease dysbiosis gene sequence heart failure heart failure with preserved ejection fraction heart infarction human hypertension immunity intestine flora metabolic syndrome X microflora nonhuman obesity personalized medicine physical activity Review
Background: This study discusses the crucial factors responsible for the progression of atherosclerotic cardiovascular disease (CVD). The interaction between the gut microbiota, heart and vessels in CVD pathogenesis is extremely complex and includes components such as direct bacterial translocation from the gut to vessels and metabolitemediated damage. To a greater extent, CVD seems to be entangled with a subtle immune system-to-microbiota interface. From among the most significant advances in recent years in this area, it is necessary to highlight the discovery of the pro-atherogenic effect of trimethylamine-N-oxide (TMAO) and changes in the activity of effector T-cells in the settings of dysbiosis. Currently, we are witnessing an explosive growth in interest in using the microbiota and interlinked cascades as a target for therapeutic interventions, including direct microbiome targeting, the attenuation of toxic metabolite-induced damage, the modulation of intestinal immunity, and dow