Compartmental modeling of skin transport
Amarah A. A., Petlin D. G., Grice J. E., Hadgraft J., Roberts M. S., Anissimov Yu. G.
European Journal of Pharmaceutics and Biopharmaceutics
Vol.130, P. 336-344
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.1016/j.ejpb.2018.07.015
Аннотация:
The primary objective of this study is to introduce a simple and flexible mathematical approach which models transport processes in skin using compartments. The main feature of the presented approach is that the rate constants for exchange between compartments are derived from physiologically relevant diffusional transport parameters. This allows for better physical interpretation of the rate constants, and limits the number of parameters for the compartmental model. The resulting compartmental solution is in good agreement with previously published solutions for the diffusion model of skin when ten or more compartments are used. It was found that the new compartmental model with three compartments provided a better fit of the previously publish water penetration data than the diffusion model. Two special cases for which it is difficult to implement the diffusion model were considered using our compartmental approach. In both cases the compartmental model predictions agreed well with t
Ключевые слова:
Compartmental model; Diffusion model; Skin transport
Article; comparative study; compartment model; controlled study; epidermis; skin; skin absorption; skin permeability; steady state; surface property; biological model; diffusion; metabolism; physiology; skin; skin absorption; theoretical model; transport at the cellular level; water; Biological Transport; Diffusion; Models, Biological; Models, Theoretical; Skin; Skin Absorption; Water
Язык текста: Английский
ISSN: 1873-3441
Amarah A. A.
Petlin D. G.
Grice J. E.
Hadgraft J.
Roberts M. S.
Anissimov Yu. G. Yurij German 1965-
Амарах А. А.
Петлин Д. Г.
Гриcе Й. Е.
Хадграфт Й.
Роберц М. С.
Аниссимов Ю. Г. Юрий Герман 1965-
Compartmental modeling of skin transport
Текст визуальный непосредственный
European Journal of Pharmaceutics and Biopharmaceutics
Elsevier Science Publisher B.V.
Vol.130 P. 336-344
2018
Статья
Compartmental model Diffusion model Skin transport
Article comparative study compartment model controlled study epidermis skin skin absorption skin permeability steady state surface property biological model diffusion metabolism physiology skin skin absorption theoretical model transport at the cellular level water Biological Transport Diffusion Models, Biological Models, Theoretical Skin Skin Absorption Water
The primary objective of this study is to introduce a simple and flexible mathematical approach which models transport processes in skin using compartments. The main feature of the presented approach is that the rate constants for exchange between compartments are derived from physiologically relevant diffusional transport parameters. This allows for better physical interpretation of the rate constants, and limits the number of parameters for the compartmental model. The resulting compartmental solution is in good agreement with previously published solutions for the diffusion model of skin when ten or more compartments are used. It was found that the new compartmental model with three compartments provided a better fit of the previously publish water penetration data than the diffusion model. Two special cases for which it is difficult to implement the diffusion model were considered using our compartmental approach. In both cases the compartmental model predictions agreed well with t