The personalized approach to antihypertensive therapy during pregnancy in terms of clinical pharmacogenetics
Игнатко И. В., Стрижаков Л. А., Флорова В. С., Мартиросова А. Л.
Вестник Российской академии медицинских наук
Т. 73, Вып. 3, С. 149-156
Опубликовано: 2018
Тип ресурса: Статья
Аннотация:
The right drug at the right dose administered to a patient in time is the goal which all medical specialists aim at when prescribing medicines to patients. Pregnancy is a condition when the principle of personalized pharmacotherapy is especially relevant. Due to the developing fetus and the occurring changes in the maternal organism, the selection of drug therapy during pregnancy is especially difficult for a clinician. This issue is tightly intertwined with clinical pharmacogenetics since the genetic code of a woman that determines the activity of the liver cytochrome, the fetus-placental barrier, and renal clearance contributes to the peculiarities of the drug metabolism during pregnancy. Additional data provides the opportunities to form therapeutic models and to determine the ways of personifying pharmacotherapy in pregnancy. The purpose of this review is to summarize the available data on the pharmacogenetics of antihypertensive drugs used during pregnancy. © 2018 Izdatel'stvo Med
Ключевые слова:
Antihypertensive therapy; Arterial hypertension; Gestational arterial hypertension; Pharmacogenetics; Preeclampsia; Pregnancy
Язык текста: Русский
ISSN: 0869-6047
Игнатко И. В. Ирина Владимировна 1968-
Стрижаков Л. А. Леонид Александрович 1976-
Флорова В. С.
Мартиросова А. Л.
Ignatko I. V. Irina Vladimirovna 1968-
Strizhakov L. A. Leonid Aleksandrovich 1976-
Florova V. S.
Martirosova A. L.
The personalized approach to antihypertensive therapy during pregnancy in terms of clinical pharmacogenetics
Текст визуальный непосредственный
Вестник Российской академии медицинских наук
Издательство "Педиатръ"
Т. 73, Вып. 3 С. 149-156
2018
Статья
Antihypertensive therapy Arterial hypertension Gestational arterial hypertension Pharmacogenetics Preeclampsia Pregnancy
The right drug at the right dose administered to a patient in time is the goal which all medical specialists aim at when prescribing medicines to patients. Pregnancy is a condition when the principle of personalized pharmacotherapy is especially relevant. Due to the developing fetus and the occurring changes in the maternal organism, the selection of drug therapy during pregnancy is especially difficult for a clinician. This issue is tightly intertwined with clinical pharmacogenetics since the genetic code of a woman that determines the activity of the liver cytochrome, the fetus-placental barrier, and renal clearance contributes to the peculiarities of the drug metabolism during pregnancy. Additional data provides the opportunities to form therapeutic models and to determine the ways of personifying pharmacotherapy in pregnancy. The purpose of this review is to summarize the available data on the pharmacogenetics of antihypertensive drugs used during pregnancy. © 2018 Izdatel'stvo Med